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Background <p>Extraction of impacted mandibular third molars are commonly associated with postoperative pain, facial swelling, and trismus. Local intra-socket drug delivery provides targeted therapy with minimal systemic drug exposure. This study compared the efficacy of dexamethasone and hyaluronic acid–soaked gelfoams in reducing postoperative sequelae.</p> Materials and Methods <p>A prospective randomized controlled study was conducted on 54 patients who underwent surgical extraction of impacted mandibular third molars. Participants were allocated into three groups (n = 18 each): Group A (control, normal saline-soaked gelfoam), Group B (dexamethasone-soaked gelfoam), and Group C (hyaluronic acid-soaked gelfoam). Facial swelling (linear measurements), interincisal mouth opening, and pain were recorded preoperatively and on postoperative days 3 and 7 using the Visual Analog Scale (VAS). Data were analyzed using one-way and repeated-measures ANOVA (p &lt; 0.05).</p> Results <p>All fifty-four participants completed the study. Baseline parameters were comparable across groups (p = 0.88, p = 0.06, p = 0.17). Facial swelling showed no significant intergroup differences on day 3 (p = 0.71) or day 7 (p = 0.74). Mouth opening differed significantly on day 3 (p = 0.021) and day 7 (p = 0.049) showed better preservation in the dexamethasone group. Pain scores showed no significant differences (p = 0.57, p = 0.82), although lower mean values were observed in the intervention groups. Antibiotic (p = 0.124) and analgesic consumption (p = 0.154) were comparable.</p> Conclusion <p>Intra-socket dexamethasone demonstrated superior efficacy in preserving mouth opening, whereas both dexamethasone and hyaluronic acid showed favorable trends in pain reduction.</p>

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Effectiveness of Intra-Socket Application of Dexamethasone- and Hyaluronic Acid-Soaked Gelfoam in Mandibular Third Molar Surgery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月3日

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  • Vanshika Bajpai,
  • Chithra Aramanadka,
  • Srikanth Gadicherla,
  • Deepak Kumar Singhal,
  • Anupam Singh,
  • Anand Deep Shukla,
  • R. Arvind

摘要

Background

Extraction of impacted mandibular third molars are commonly associated with postoperative pain, facial swelling, and trismus. Local intra-socket drug delivery provides targeted therapy with minimal systemic drug exposure. This study compared the efficacy of dexamethasone and hyaluronic acid–soaked gelfoams in reducing postoperative sequelae.

Materials and Methods

A prospective randomized controlled study was conducted on 54 patients who underwent surgical extraction of impacted mandibular third molars. Participants were allocated into three groups (n = 18 each): Group A (control, normal saline-soaked gelfoam), Group B (dexamethasone-soaked gelfoam), and Group C (hyaluronic acid-soaked gelfoam). Facial swelling (linear measurements), interincisal mouth opening, and pain were recorded preoperatively and on postoperative days 3 and 7 using the Visual Analog Scale (VAS). Data were analyzed using one-way and repeated-measures ANOVA (p < 0.05).

Results

All fifty-four participants completed the study. Baseline parameters were comparable across groups (p = 0.88, p = 0.06, p = 0.17). Facial swelling showed no significant intergroup differences on day 3 (p = 0.71) or day 7 (p = 0.74). Mouth opening differed significantly on day 3 (p = 0.021) and day 7 (p = 0.049) showed better preservation in the dexamethasone group. Pain scores showed no significant differences (p = 0.57, p = 0.82), although lower mean values were observed in the intervention groups. Antibiotic (p = 0.124) and analgesic consumption (p = 0.154) were comparable.

Conclusion

Intra-socket dexamethasone demonstrated superior efficacy in preserving mouth opening, whereas both dexamethasone and hyaluronic acid showed favorable trends in pain reduction.