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Background <p>Polymorphous adenocarcinoma (PAC) is a rare malignant neoplasm of minor salivary gland. It often poses diagnostic difficulty due to its morphological overlap with lesions like adenoid cystic carcinoma (AdCC) and pleomorphic adenoma. The cases are thereby needed to be documented in literature highlighting the diagnostic challenges which will help in improving the evidence-based approach for treating challenging lesions.</p> Case Presentation <p>A 75-year-old male presented with a one-month history of dysphagia and an erosive lesion noted at the hard-soft palate junction. Incisional biopsy’s histological examination and immunohistochemistry (S100+, Vimentin+, MYB-) confirmed the diagnosis of PAC. The patient underwent complete surgical excision and repair with no recurrence noted after six months.</p> Conclusion <p>This case underscores the diagnostic challenge of PAC and highlights the critical role of histopathological examination and immunohistochemistry particularly in differentiating such cases from AdCC to guide appropriate management and thereby ensure favourable outcomes.</p>

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Polymorphous Adenocarcinoma of Minor Salivary Glands on Soft Palate: A Rare Case Report

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Arushi Tomar,
  • Rangeet Bhadra

摘要

Background

Polymorphous adenocarcinoma (PAC) is a rare malignant neoplasm of minor salivary gland. It often poses diagnostic difficulty due to its morphological overlap with lesions like adenoid cystic carcinoma (AdCC) and pleomorphic adenoma. The cases are thereby needed to be documented in literature highlighting the diagnostic challenges which will help in improving the evidence-based approach for treating challenging lesions.

Case Presentation

A 75-year-old male presented with a one-month history of dysphagia and an erosive lesion noted at the hard-soft palate junction. Incisional biopsy’s histological examination and immunohistochemistry (S100+, Vimentin+, MYB-) confirmed the diagnosis of PAC. The patient underwent complete surgical excision and repair with no recurrence noted after six months.

Conclusion

This case underscores the diagnostic challenge of PAC and highlights the critical role of histopathological examination and immunohistochemistry particularly in differentiating such cases from AdCC to guide appropriate management and thereby ensure favourable outcomes.