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<p>Peripheral odontogenic fibroma (PODF) is a relatively rare, benign extraosseous odontogenic tumor derived from odontogenic ectomesenchyme, characterized by a mature fibrous stroma containing inactive islands of odontogenic epithelium. This case report describes a 52-year-old female who presented with a recurrent labial gingival mass involving the upper left lateral incisor–canine region. The lesion had been excised one year earlier, with a pathological diagnosis of pyogenic granuloma. The recurrent lesion was subsequently excised under local anesthesia, along with scaling and root planing of the affected area. Histopathological examination revealed PODF (with calcification). Awareness of the clinical presentation, differential diagnosis, and histopathological features of such lesions is crucial for achieving an accurate diagnosis. Given the shared potential for mineralized tissue formation in PODF and peripheral ossifying fibroma (POF), diagnostic confusion may occur. The clinical and histopathologic differential diagnoses of PODF and POF are discussed.</p>

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Peripheral Odontogenic Fibroma with Calcification After Previous Excision of a Lesion Diagnosed as Pyogenic Granuloma: A Case Report and Clinicopathologic Consideration

  • 期刊论文

  • 发表日期：

    2026年5月21日

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  • Pornpop Rattana-arpha

摘要

Peripheral odontogenic fibroma (PODF) is a relatively rare, benign extraosseous odontogenic tumor derived from odontogenic ectomesenchyme, characterized by a mature fibrous stroma containing inactive islands of odontogenic epithelium. This case report describes a 52-year-old female who presented with a recurrent labial gingival mass involving the upper left lateral incisor–canine region. The lesion had been excised one year earlier, with a pathological diagnosis of pyogenic granuloma. The recurrent lesion was subsequently excised under local anesthesia, along with scaling and root planing of the affected area. Histopathological examination revealed PODF (with calcification). Awareness of the clinical presentation, differential diagnosis, and histopathological features of such lesions is crucial for achieving an accurate diagnosis. Given the shared potential for mineralized tissue formation in PODF and peripheral ossifying fibroma (POF), diagnostic confusion may occur. The clinical and histopathologic differential diagnoses of PODF and POF are discussed.