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Background <p>Alveolar bone resorption following extraction can compromise future prosthetic rehabilitation. Collagen plugs have been proposed to improve healing, but evidence on their standalone effect remains limited.</p> Aim <p>To evaluate the effectiveness of a biodegradable collagen plug in post-orthodontic premolar extraction sockets using a split-mouth design.</p> Materials and Methods <p>Twenty patients (40 sites) undergoing bilateral maxillary premolar extractions were included. One socket received a collagen plug and the contralateral served as control. The study was prospectively registered with the Clinical Trials Registry – India (CTRI/2024/03/063892). Soft tissue healing was assessed at 10 days using the Landry index, and bone density was evaluated using RVG gray-scale analysis at 3 months.</p> Results <p>Soft tissue healing was significantly better in the collagen group (<i>p</i> &lt; 0.001). Bone density was significantly higher at 3 months in the collagen group (<i>p</i> = 0.031). No adverse effects were observed.</p> Conclusion <p>Collagen plugs improve early soft tissue healing and bone density in orthodontic extraction sockets. However, long-term clinical relevance requires further investigation.</p>

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Alveolar Bone preservation of Post-orthodontic Extraction Sockets Using a Standalone Biodegradable Collagen Plug: A Randomized Split-Mouth Clinico–radiographic Study

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Damini Goel,
  • Pushkar P. Waknis,
  • Lakshmi Shetty,
  • Rushil Patel

摘要

Background

Alveolar bone resorption following extraction can compromise future prosthetic rehabilitation. Collagen plugs have been proposed to improve healing, but evidence on their standalone effect remains limited.

Aim

To evaluate the effectiveness of a biodegradable collagen plug in post-orthodontic premolar extraction sockets using a split-mouth design.

Materials and Methods

Twenty patients (40 sites) undergoing bilateral maxillary premolar extractions were included. One socket received a collagen plug and the contralateral served as control. The study was prospectively registered with the Clinical Trials Registry – India (CTRI/2024/03/063892). Soft tissue healing was assessed at 10 days using the Landry index, and bone density was evaluated using RVG gray-scale analysis at 3 months.

Results

Soft tissue healing was significantly better in the collagen group (p < 0.001). Bone density was significantly higher at 3 months in the collagen group (p = 0.031). No adverse effects were observed.

Conclusion

Collagen plugs improve early soft tissue healing and bone density in orthodontic extraction sockets. However, long-term clinical relevance requires further investigation.