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Objective <p>Oral environment is a unique environment where healing is complicated by presence of microorganisms and saliva. Various materials fail to provide necessary aid in enhancing healing due to this. Propolis or bee glue is a resinous substance which recent studies have shown to possess positive effects on wound healing. The purpose of this study was to evaluate the efficiency of propolis gel in healing of intraoral wounds.</p> Materials and Methods <p>A prospective single blinded clinical trial done where 14 patients requiring alveoloplasty bilaterally were selected. Propolis gel (10%) was applied on one surgical site whereas the other site was allowed to heal by primary intention alone with an interval of 4 weeks between both procedures. Healing was assessed using Landry, Turnbull and Howley index on postoperative days 1,7 and 21. Mann Whitney U test and Friedman test were used to compare the variables assessed.</p> Results <p>Statistically significant results were observed on comparison of healing indices between groups A (Propolis gel) and B (Control) on POD 1 and 7 indicating propolis has a positive effect on intra oral wound healing. During the initial stages of wound healing, better results were observed in the propolis group compared to the control group.</p> Conclusion <p>According to the results of this study, Propolis in gel form has shown to improve wound healing in intra-oral wounds. This study, although conducted with a limited sample size, is sufficient to give a basic account of the behaviour of propolis in clinical practice, as no similar studies were present at the time which accounted for any adverse effects. Further studies are required to establish their active role in routine clinical use.</p>

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Comparative Evaluation of Soft Tissue Healing of Intra Oral Wounds with and Without Propolis Gel: A Split Mouth Randomized Clinical Trial

  • 期刊论文

  • 发表日期：

    2026年3月14日

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  • Sherwin Samuel,
  • Kalyani Bhate,
  • Akash Muralidharan,
  • U. Manoj Kumar,
  • Rushabh Chordia

摘要

Objective

Oral environment is a unique environment where healing is complicated by presence of microorganisms and saliva. Various materials fail to provide necessary aid in enhancing healing due to this. Propolis or bee glue is a resinous substance which recent studies have shown to possess positive effects on wound healing. The purpose of this study was to evaluate the efficiency of propolis gel in healing of intraoral wounds.

Materials and Methods

A prospective single blinded clinical trial done where 14 patients requiring alveoloplasty bilaterally were selected. Propolis gel (10%) was applied on one surgical site whereas the other site was allowed to heal by primary intention alone with an interval of 4 weeks between both procedures. Healing was assessed using Landry, Turnbull and Howley index on postoperative days 1,7 and 21. Mann Whitney U test and Friedman test were used to compare the variables assessed.

Results

Statistically significant results were observed on comparison of healing indices between groups A (Propolis gel) and B (Control) on POD 1 and 7 indicating propolis has a positive effect on intra oral wound healing. During the initial stages of wound healing, better results were observed in the propolis group compared to the control group.

Conclusion

According to the results of this study, Propolis in gel form has shown to improve wound healing in intra-oral wounds. This study, although conducted with a limited sample size, is sufficient to give a basic account of the behaviour of propolis in clinical practice, as no similar studies were present at the time which accounted for any adverse effects. Further studies are required to establish their active role in routine clinical use.