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Background <p>Synovial sarcoma, a malignant mesenchymal neoplasm, is predominantly linked to the extremities. Nonetheless, its occurrence in the head and neck area, especially within the masseter muscle, is exceedingly uncommon. This uniqueness highlights the importance of each instance in elucidating the intricacies of its behavior and management approaches.</p> Case report <p>A 30-year-old Female Had Recurring Discomfort and Swelling in the Right Facial region. She Had A Previous Diagnosis of A Schwannoma in the Same area, Which Was Excised A Decade ago. Notwithstanding Surgical excision, her Symptoms continued, and She Remained Under observation. Two Months before the presentation, the Swelling reappeared, Accompanied by acute, Persistent Discomfort. The MRI Indicated A Hypointense Lesion in the Right Masseter muscle. The Surgical re-excision Disclosed A well-encapsulated Neoplasm. Histopathology Revealed A Hypercellular Spindle Cell Neoplasm Organised in a biphasic pattern, with regions of glandular differentiation, nuclear pleomorphism, and atypical mitotic figures. Immunohistochemistry exhibited positivity for TLE, H-Caldesmon, CD10, and Vimentin, but S100 and CD34 demonstrated negativity. Fluorescence in situ hybridisation validated the SS18::X2 gene rearrangement. A definitive diagnosis of biphasic synovial sarcoma was made.</p> Conclusion <p>This case underscores the peculiar manifestation of synovial sarcoma in the masseteric area occurring in a patient with a prior history of Schwannoma.</p>

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Synovial Sarcoma of the Masseteric Region Arising in a Patient with Prior Schwannoma: A Rare Case Presentation and Review of Literature

  • 期刊论文

  • 发表日期：

    2026年2月13日

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  • Aarushi Garg,
  • Priya Kumar,
  • Jeyaseelan Augustine,
  • Zainab Chaudhary,
  • Pankaj Sharma,
  • Aadithya B. Urs

摘要

Background

Synovial sarcoma, a malignant mesenchymal neoplasm, is predominantly linked to the extremities. Nonetheless, its occurrence in the head and neck area, especially within the masseter muscle, is exceedingly uncommon. This uniqueness highlights the importance of each instance in elucidating the intricacies of its behavior and management approaches.

Case report

A 30-year-old Female Had Recurring Discomfort and Swelling in the Right Facial region. She Had A Previous Diagnosis of A Schwannoma in the Same area, Which Was Excised A Decade ago. Notwithstanding Surgical excision, her Symptoms continued, and She Remained Under observation. Two Months before the presentation, the Swelling reappeared, Accompanied by acute, Persistent Discomfort. The MRI Indicated A Hypointense Lesion in the Right Masseter muscle. The Surgical re-excision Disclosed A well-encapsulated Neoplasm. Histopathology Revealed A Hypercellular Spindle Cell Neoplasm Organised in a biphasic pattern, with regions of glandular differentiation, nuclear pleomorphism, and atypical mitotic figures. Immunohistochemistry exhibited positivity for TLE, H-Caldesmon, CD10, and Vimentin, but S100 and CD34 demonstrated negativity. Fluorescence in situ hybridisation validated the SS18::X2 gene rearrangement. A definitive diagnosis of biphasic synovial sarcoma was made.

Conclusion

This case underscores the peculiar manifestation of synovial sarcoma in the masseteric area occurring in a patient with a prior history of Schwannoma.