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Background <p>Lidocaine with adrenaline is the most commonly used local anaesthetic in minor oral surgery, yet postoperative analgesics are often required.</p> Aim <p>To evaluate the intraoperative efficacy of lidocaine-bupivacaine solution in mandibular third molar extractions and its postoperative advantages compared to conventional lidocaine with adrenaline.</p> Materials and Methods <p>The study included 23 patients requiring surgical removal of bilaterally impacted mandibular third molars where inferior alveolar nerve block was administered. 1:1 lidocaine-bupivacaine solution was administered on one side (study group) and lidocaine with adrenaline was administered on the contralateral side (control group). Pain was assessed intraoperatively and postoperatively using Visual Analogue Scale (VAS) scores.</p> Results <p>The onset of anaesthesia was faster in the control group. Intraoperatively, the study group reported higher VAS scores during tooth sectioning, while the controlgroup reported higher scores during closure. Postoperatively, the control group experienced more pain and required analgesics, whereas the study group did not need any postoperative analgesics.</p> Conclusion <p>Lidocaine-bupivacaine solution is a viable alternative to lidocaine with adrenaline, particularly for patients allergic to NSAIDs or when adrenaline use is contraindicated.</p>

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Comparison of Efficacy of Lidocaine-Bupivacaine Solution to Lidocaine with Adrenaline Solution in Mandibular Third Molar Surgery: A Randomized Split-Mouth Double Blind Study

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • V. V. S. S. Koushik Reddy,
  • Y. W. Bharath,
  • N. Viveka Vardhan Reddy,
  • Ritesh Rajan,
  • Dinesh Jhawar,
  • P. Abhinand

摘要

Background

Lidocaine with adrenaline is the most commonly used local anaesthetic in minor oral surgery, yet postoperative analgesics are often required.

Aim

To evaluate the intraoperative efficacy of lidocaine-bupivacaine solution in mandibular third molar extractions and its postoperative advantages compared to conventional lidocaine with adrenaline.

Materials and Methods

The study included 23 patients requiring surgical removal of bilaterally impacted mandibular third molars where inferior alveolar nerve block was administered. 1:1 lidocaine-bupivacaine solution was administered on one side (study group) and lidocaine with adrenaline was administered on the contralateral side (control group). Pain was assessed intraoperatively and postoperatively using Visual Analogue Scale (VAS) scores.

Results

The onset of anaesthesia was faster in the control group. Intraoperatively, the study group reported higher VAS scores during tooth sectioning, while the controlgroup reported higher scores during closure. Postoperatively, the control group experienced more pain and required analgesics, whereas the study group did not need any postoperative analgesics.

Conclusion

Lidocaine-bupivacaine solution is a viable alternative to lidocaine with adrenaline, particularly for patients allergic to NSAIDs or when adrenaline use is contraindicated.