Scholarlink

Objective <p>The precise dose–response relationship between areca nut-based products (ANBP) and OSMF severity remains underexplored. This study investigates the co-relation between the pattern of ANBP consumption to the clinical progression of the disease.</p> Methodology <p>315 patients diagnosed with OSMF (grades III and IVa) were evaluated in this prospective, observational study at AMC Dental College and Hospital, Ahmedabad (2017–2024). The study recorded the impact of ANBP consumption in terms of duration (years), frequency (times/day), and total product intake (packets/day) on mouth opening using statistical modeling using multiple linear regression.</p> Results <p>The study revealed a striking dose-dependent effect, with the total number of ANBP consumed per day emerging as the strongest predictor of OSMF severity (1.44&#xa0;mm reduction in mouth opening per additional product; <i>p</i> &lt; 0.05). Consumption frequency also significantly accelerated disease progression (0.46&#xa0;mm reduction per additional use/day), while duration, though contributory, had a comparatively lower impact (0.05&#xa0;mm/year).</p> Importance <p>This study contributes the first quantitative evidence demonstrating that total daily ANBP consumption acts as a primary driver of OSMF progression, surpassing duration and frequency of the habit.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Oral Submucous Fibrosis: Dose Response Analysis of Pattern of Consumption of Arecanut and its By-Products on the Clinical Progression of Disease—A Prospective Clinical Study

  • 期刊论文

  • 发表日期：

    2026年1月23日

查看全文
  • Shital Patel,
  • Taher Rupawala,
  • Shyam Chauhan,
  • Zenish Bhatti,
  • Sanjay Makwana,
  • Yashasvi Chavda

摘要

Objective

The precise dose–response relationship between areca nut-based products (ANBP) and OSMF severity remains underexplored. This study investigates the co-relation between the pattern of ANBP consumption to the clinical progression of the disease.

Methodology

315 patients diagnosed with OSMF (grades III and IVa) were evaluated in this prospective, observational study at AMC Dental College and Hospital, Ahmedabad (2017–2024). The study recorded the impact of ANBP consumption in terms of duration (years), frequency (times/day), and total product intake (packets/day) on mouth opening using statistical modeling using multiple linear regression.

Results

The study revealed a striking dose-dependent effect, with the total number of ANBP consumed per day emerging as the strongest predictor of OSMF severity (1.44 mm reduction in mouth opening per additional product; p < 0.05). Consumption frequency also significantly accelerated disease progression (0.46 mm reduction per additional use/day), while duration, though contributory, had a comparatively lower impact (0.05 mm/year).

Importance

This study contributes the first quantitative evidence demonstrating that total daily ANBP consumption acts as a primary driver of OSMF progression, surpassing duration and frequency of the habit.