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Objective <p>To estimate the prevalence of overall radiation-induced xerostomia (RIX) and moderate to severe RIX in patients with Head and Neck Cancer (HNC).</p> Methods <p>This study systematically retrieved observational studies reporting the prevalence of RIX in patients with HNC from the following databases: PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, Sinomed, CNKI, Wanfang, and the VIP Database. These studies covered publications from database establishment to July 2025. Two researchers independently screened the records and extracted the data. Study quality was assessed using the Newcastle-Ottawa Scale for cohort studies, and the Agency for Healthcare Research and Quality criteria for cross-sectional studies. The meta-analysis pooled the prevalence of both overall and moderate to severe RIX as outcomes, with subgroup analyses stratified by assessment time, study quality, assessment tool, sample size, cancer types and study countries. All statistical analyses were performed using Stata 18.0.</p> Results <p>A total of 29 studies comprising 6,735 patients were included. The pooled prevalence of RIX in patients with HNC was 80.7% (95% <i>CI</i>: 0.68–0.908; <i>I</i>² = 98.9%; <i>P</i> &lt; 0.001; <i>n</i> = 5,172), and the prevalence of moderate to severe RIX was 35.1% (95% <i>CI</i>: 0. 205–0.512; <i>I</i>² = 99.0%; <i>n</i> = 4,494).</p> Conclusion <p>The overall prevalence of RIX was significantly high in patients with HNC. Clinical care providers should pay more attention to RIX patients, early identification and screening of high-risk groups, and intervene as early as possible to reduce the prevalence of RIX.</p> <p><i> Trial Registration</i>: PROSPERO (ref: CRD42025634247)</p>

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The Prevalence of Radiation-Induced Xerostomia in Patients with Head and Neck Cancer: A Systematic Review and Meta-analysis

  • 期刊论文

  • 发表日期：

    2026年2月19日

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  • Lan Chen,
  • Jing Chen,
  • Ya Huang,
  • Jingjing Wu,
  • Mi Zeng,
  • Fei Wu,
  • Liyu Wang,
  • Huiru Zhang,
  • Huijun Quan,
  • Guqing Zeng

摘要

Objective

To estimate the prevalence of overall radiation-induced xerostomia (RIX) and moderate to severe RIX in patients with Head and Neck Cancer (HNC).

Methods

This study systematically retrieved observational studies reporting the prevalence of RIX in patients with HNC from the following databases: PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, Sinomed, CNKI, Wanfang, and the VIP Database. These studies covered publications from database establishment to July 2025. Two researchers independently screened the records and extracted the data. Study quality was assessed using the Newcastle-Ottawa Scale for cohort studies, and the Agency for Healthcare Research and Quality criteria for cross-sectional studies. The meta-analysis pooled the prevalence of both overall and moderate to severe RIX as outcomes, with subgroup analyses stratified by assessment time, study quality, assessment tool, sample size, cancer types and study countries. All statistical analyses were performed using Stata 18.0.

Results

A total of 29 studies comprising 6,735 patients were included. The pooled prevalence of RIX in patients with HNC was 80.7% (95% CI: 0.68–0.908; I² = 98.9%; P < 0.001; n = 5,172), and the prevalence of moderate to severe RIX was 35.1% (95% CI: 0. 205–0.512; I² = 99.0%; n = 4,494).

Conclusion

The overall prevalence of RIX was significantly high in patients with HNC. Clinical care providers should pay more attention to RIX patients, early identification and screening of high-risk groups, and intervene as early as possible to reduce the prevalence of RIX.

Trial Registration: PROSPERO (ref: CRD42025634247)