Background <p>The purpose of this study was to identify risk factors associated with the recurrence of mandibular osteomyelitis after sequestrectomy in patients with and without osteoradionecrosis (ORN) or medication-related osteonecrosis (MRONJ).</p> Methods <p>From 01/01/2017 through 01/01/2022 charts were retrospectively reviewed from patients who underwent mandibular sequestrectomy. The primary outcome evaluated was mandibular osteomyelitis recurrence after sequestrectomy. Descriptive and bivariate statistics were used to identify risk factors associated with osteomyelitis recurrence rates with <i>p</i> &lt; 0.05 being considered statistically significant.</p> Results <p>This study consisted of 35 patients with ORN/MRONJ and 28 patients that had only osteomyelitis. Patients with ORN/MRONJ had statistically significantly more rates of osteomyelitis recurrence compared to those without (37.1% vs. 10.7%, <i>p</i> = 0.0176). Interestingly patients without ORN/MRONJ had higher rates of infectious diseases consultation (<i>p</i> = 0.0059) and the utilization of infectious disease consultation was associated with statistically significant reductions in osteomyelitis recurrence (<i>p</i> = 0.0162).</p> Conclusions <p>When infectious diseases consultation was utilized, patients had lower rates of mandibular osteomyelitis recurrence. Consequently, implementing protocols that prioritize multidisciplinary approaches to treat these patients likely will reduce morbidity. Yet, further studies are needed to understand barriers to utilizing infectious diseases consultations.</p>