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<p>Carcinoma cuniculatum (CC) is a rare and under-recognized well-differentiated variant of squamous cell carcinoma (SCC), characterized histopathologically by the presence of deep keratin-filled crypts and minimal cytological atypia. Although CC is more commonly encountered in the plantar region, intraoral manifestations—particularly in the mandibular alveolus—are exceedingly rare. We report a unique case of mandibular CC in a 56-year-old male with a prior history of oral SCC of the tongue, treated with surgery followed by adjuvant chemotherapy and radiotherapy. The case highlights the diagnostic and therapeutic challenges in differentiating recurrent disease from second primary malignancy in previously treated patients.</p>

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An Unusual Case Report of Mandibular Carcinoma Cuniculatum as a Second Primary Malignancy

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Samyuktha Aarthi Sivasubramani,
  • Suganya Panneer Selvam,
  • Deepak Pandiar

摘要

Carcinoma cuniculatum (CC) is a rare and under-recognized well-differentiated variant of squamous cell carcinoma (SCC), characterized histopathologically by the presence of deep keratin-filled crypts and minimal cytological atypia. Although CC is more commonly encountered in the plantar region, intraoral manifestations—particularly in the mandibular alveolus—are exceedingly rare. We report a unique case of mandibular CC in a 56-year-old male with a prior history of oral SCC of the tongue, treated with surgery followed by adjuvant chemotherapy and radiotherapy. The case highlights the diagnostic and therapeutic challenges in differentiating recurrent disease from second primary malignancy in previously treated patients.