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Background <p>To review the literature on the effectiveness of intra-articular injection following arthrocentesis for the management of internal derangement (disc displacement without reduction) of TMJ. The present systematic review addresses the following focus question: Which is the better alternative out of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid for internal derangement(disc displacement without reduction) t of TMJ?</p> Methods <p>Electronic and manual literature searches were conducted on databases: for studies published until January 2023 to collect information about the effect of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid on internal derangement(disc displacement without reduction) of TMJ. Systematic literature review was performed following the PRISMA guidelines to identify the studies evaluating better alternative out of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid in patients suffering from internal derangement(disc displacement without reduction) of TMJ. Human randomized and non-randomized controlled trials and prospective and retrospective cohort studies were included in the study. The case reports, technical reports, animal studies, cadaver studies, in vitro studies, systematic reviews and review papers were excluded.</p> Results <p>122 articles published between the time period from January 2014 to January 2023 were identified. 17 articles remained when exclusion criteria were applied. These 17 articles included studies containing a total of 794 patients, who were evaluated for pain score using VAS, maximum mouth opening (MMO), lateral movement, and clicking. We observed that pain and clicking was minimum with L/I PRF, followed by PRP and Corticosteroids (CS) and maximum in Hyaluronic acid (HA). Furthermore, mouth opening and lateral movement was maximum in cases treated with L/I PRF, followed by PRP and Corticosteroids (CS) and least in patients treated with Hyaluronic acid (HA). Overall, a significant relation ((p-value was observed between all the groups in relation to all selected studies.</p> Conclusion <p>Due to heterogeneity and variability in study designs and lack of reporting on confounding factors, definitive conclusions on better alternative out of PRP v/s I PRF v/s sodium hyaluronate v/s corticosteroid on TMJ derangements cannot be drawn. Future well-designed long-term randomized controlled trials are necessary to reveal the necessary correlation between various parameters.</p>

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Comparative Systematic Review and Meta-Analysis Evaluating Platelet-Rich Plasma, Injectable Platelet-Rich Fibrin, Sodium Hyaluronate, and Corticosteroids as Intra-articular Injectables Following Arthrocentesis for Managing Temporomandibular Joint Internal Derangement

  • 期刊论文

  • 发表日期：

    2025年12月13日

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  • Sapna Tandon,
  • Saurabh Srivastava,
  • Anusmita Barman,
  • Pandey Kiran,
  • Chhavi Sharma,
  • Mohd Adil

摘要

Background

To review the literature on the effectiveness of intra-articular injection following arthrocentesis for the management of internal derangement (disc displacement without reduction) of TMJ. The present systematic review addresses the following focus question: Which is the better alternative out of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid for internal derangement(disc displacement without reduction) t of TMJ?

Methods

Electronic and manual literature searches were conducted on databases: for studies published until January 2023 to collect information about the effect of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid on internal derangement(disc displacement without reduction) of TMJ. Systematic literature review was performed following the PRISMA guidelines to identify the studies evaluating better alternative out of PRP v/s I-PRF v/s sodium hyaluronate v/s corticosteroid in patients suffering from internal derangement(disc displacement without reduction) of TMJ. Human randomized and non-randomized controlled trials and prospective and retrospective cohort studies were included in the study. The case reports, technical reports, animal studies, cadaver studies, in vitro studies, systematic reviews and review papers were excluded.

Results

122 articles published between the time period from January 2014 to January 2023 were identified. 17 articles remained when exclusion criteria were applied. These 17 articles included studies containing a total of 794 patients, who were evaluated for pain score using VAS, maximum mouth opening (MMO), lateral movement, and clicking. We observed that pain and clicking was minimum with L/I PRF, followed by PRP and Corticosteroids (CS) and maximum in Hyaluronic acid (HA). Furthermore, mouth opening and lateral movement was maximum in cases treated with L/I PRF, followed by PRP and Corticosteroids (CS) and least in patients treated with Hyaluronic acid (HA). Overall, a significant relation ((p-value was observed between all the groups in relation to all selected studies.

Conclusion

Due to heterogeneity and variability in study designs and lack of reporting on confounding factors, definitive conclusions on better alternative out of PRP v/s I PRF v/s sodium hyaluronate v/s corticosteroid on TMJ derangements cannot be drawn. Future well-designed long-term randomized controlled trials are necessary to reveal the necessary correlation between various parameters.