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Introduction <p>The procedure of dental extraction has been associated with an unpleasant response. Ideal postoperative pain management requires elimination of pain and discomfort to the patient. Transdermal patches have in the recent past been developed as innovative topical delivery systems for diclofenac and other NSAIDs, offering the advantage of sustained drug delivery with reduced incidence of systemic adverse effects due to lower plasma concentrations.</p> Materials and Method <p>This is a comparative interventional study for comparing the efficacy of transdermal diclofenac and oral diclofenac in management of post operative pain in extraction and patient compliance. The study was conducted on 62 patients indicated for extraction of mandibular molars.</p> Results <p>There was significant difference between the two groups in terms of pain score, compliance and gastrointestinal irritability with the diclofenac patch proving to be better than the oral intake of the drug.</p> Conclusion <p>Diclofenac tablets provided quicker pain relief initially, while transdermal patches demonstrated better sustained relief over a longer period. Patients showed a higher preference for the tablet formulation, indicating a tendency to Favor oral medications. Gastrointestinal irritation was reported by some tablet users, whereas the patch group experienced no such issues. The absence of gastrointestinal side effects in the patch group suggests a safer profile for patients sensitive to NSAIDs, with no skin allergies reported in either group.</p>

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Comparison of Effectiveness and Compliance of Diclofenac in a Transdermal Mode as Compared to Oral Diclofenac After Extractions of Mandibular Molars

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • D. Supriya,
  • Suresh Menon

摘要

Introduction

The procedure of dental extraction has been associated with an unpleasant response. Ideal postoperative pain management requires elimination of pain and discomfort to the patient. Transdermal patches have in the recent past been developed as innovative topical delivery systems for diclofenac and other NSAIDs, offering the advantage of sustained drug delivery with reduced incidence of systemic adverse effects due to lower plasma concentrations.

Materials and Method

This is a comparative interventional study for comparing the efficacy of transdermal diclofenac and oral diclofenac in management of post operative pain in extraction and patient compliance. The study was conducted on 62 patients indicated for extraction of mandibular molars.

Results

There was significant difference between the two groups in terms of pain score, compliance and gastrointestinal irritability with the diclofenac patch proving to be better than the oral intake of the drug.

Conclusion

Diclofenac tablets provided quicker pain relief initially, while transdermal patches demonstrated better sustained relief over a longer period. Patients showed a higher preference for the tablet formulation, indicating a tendency to Favor oral medications. Gastrointestinal irritation was reported by some tablet users, whereas the patch group experienced no such issues. The absence of gastrointestinal side effects in the patch group suggests a safer profile for patients sensitive to NSAIDs, with no skin allergies reported in either group.