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Objective <p>This prospective, randomized, split-mouth, single-blinded clinical study compared the efficacy of simvastatin and melatonin in promoting alveolar bone regeneration and postoperative healing after mandibular third molar extraction.</p> Methods <p>Thirty healthy patients undergoing bilateral mandibular third molar extractions were recruited. Simvastatin (10&#xa0;mg) was applied to one extraction site, and melatonin (3&#xa0;mg) to the contralateral site using a gelatin sponge carrier. Pain, soft tissue healing, and bone regeneration were evaluated using the visual analog scale (VAS), Landry’s Healing Index, and grayscale histogram analysis of digital radiographs over 12&#xa0;weeks.</p> Results <p>Simvastatin-treated sockets demonstrated significantly higher grayscale values at weeks 1 (<i>P</i> &lt; 0.001) and 4 (<i>P</i> = 0.009), indicating enhanced bone regeneration. VAS pain scores were also significantly lower in the simvastatin group at week 1 (<i>P</i> = 0.004). No significant differences were observed in soft tissue healing.</p> Conclusion <p>Simvastatin demonstrated superior early osteogenic potential and pain reduction compared to melatonin in third molar extraction sockets. Its accessibility and cost-effectiveness support its clinical utility in socket preservation.</p>

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Simvastatin Outperforms Melatonin in Early Alveolar Bone Regeneration Following Mandibular Third Molar Extraction: A Prospective Split-Mouth Study

  • 期刊论文

  • 发表日期：

    2025年10月10日

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  • Subham Kumar Sinha,
  • Asutosh Das

摘要

Objective

This prospective, randomized, split-mouth, single-blinded clinical study compared the efficacy of simvastatin and melatonin in promoting alveolar bone regeneration and postoperative healing after mandibular third molar extraction.

Methods

Thirty healthy patients undergoing bilateral mandibular third molar extractions were recruited. Simvastatin (10 mg) was applied to one extraction site, and melatonin (3 mg) to the contralateral site using a gelatin sponge carrier. Pain, soft tissue healing, and bone regeneration were evaluated using the visual analog scale (VAS), Landry’s Healing Index, and grayscale histogram analysis of digital radiographs over 12 weeks.

Results

Simvastatin-treated sockets demonstrated significantly higher grayscale values at weeks 1 (P < 0.001) and 4 (P = 0.009), indicating enhanced bone regeneration. VAS pain scores were also significantly lower in the simvastatin group at week 1 (P = 0.004). No significant differences were observed in soft tissue healing.

Conclusion

Simvastatin demonstrated superior early osteogenic potential and pain reduction compared to melatonin in third molar extraction sockets. Its accessibility and cost-effectiveness support its clinical utility in socket preservation.