Background <p>Nasopalatine duct cyst (NPDC) is the most common non-odontogenic cyst of the oral and maxillofacial region. It arises from the epithelial remnants of the nasopalatine duct. Despite its prevalence, the clinicopathological features of NPDC remain underreported. The study aimed to evaluate the clinicopathological features of NPDC, including clinical presentation, radiological findings, and histological aspects, in a retrospective cohort of patients treated at a single institution.</p> Methodology <p>A retrospective analysis was conducted using clinical records of patients diagnosed with NPDC between 2007 and 2024 after seeking clearance from the institutional ethical clearance board. Data collected included age, gender, clinical presentation (symptoms and size), location, radiological findings, and histopathological characteristics.</p> Results <p>Ten cases of NPDC were identified, with a prevalence of 0.15%. The mean age of patients was 32&#xa0;years, with a higher incidence observed in male patients. The most common presenting symptoms were pain and swelling. Radiologically, all the NPDCs were located in the midline of the anterior maxilla, presenting as a well-defined radiolucent lesion. Histopathological examination revealed a diverse pattern across the cases.</p> Conclusion <p>This study provides a comprehensive analysis of the clinicopathological features of NPDC, highlighting the importance of early diagnosis and appropriate management. NPDCs typically present with non-specific symptoms and can be effectively diagnosed through radiological and histological examination.</p>