Background Bone defects are a frequent challenge in dental practices, and their reconstruction poses significant difficulties within orthopedic treatment. This study delves into the potential of methylsulfonylmethane (MSM), known for its osteoinductive properties, to promote bone healing in bony defects created in the mandibles of rabbits. Materials and Methods We discussed an experimental study involving twelve male New Zealand rabbits, each subjected to four surgically induced defects in their mandibles. These defects were organized into four groups: two experimental groups and two control groups. In the experimental setup, one set of defects was treated with Gelfoam and a 20 mM concentration of MSM, while another received Gelfoam with a 10 mM concentration of MSM. The control groups consisted of one filled with Gelfoam alone (positive control) and another that was left to heal naturally (negative control). We assessed the bone repair histologically after euthanizing the rabbits at three different time points: 4, 8, and 12 weeks post-surgery, analyzing four rabbits at each time interval. Results of Study The results revealed significant differences in osteoblast cell activity between the MSM-treated groups compared to the Gelfoam and control groups (p < 0.001 for both concentrations, p = 0.038 for 10 mM, and p = 0.013 for 20 mM). Notably, the comparison between the two MSM groups showed further statistical significance (p = 0.004). However, there were no significant differences between the Gelfoam alone and the control groups (p = 0.468). Additionally, the degree of osteoid tissue formation was significantly greater in the MSM groups compared to Gelfoam and control groups (p = 0.021 for 20 mM, p = 0.028 for 10 mM, both p < 0.05 for other comparisons). Again, there were no significant differences between the Gelfoam and control groups (p = 0.854). Conclusion As a result, the study demonstrates that the topical application of methylsulfonylmethane (MSM) serves as an effective therapeutic approach to enhance bone formation and expedite the healing of bone defects in rabbits. These findings hold considerable implications for oral oncology, where the regeneration of bone structure is crucial for patient recovery and improved outcomes in dental and maxillofacial treatments.

Enhancing Bone Regeneration: The Role of Methylsulfonylmethane (MSM) in Oncology and Maxillofacial Surgery

期刊论文
发表日期：

2025年8月22日

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Bayan Alnehlawi,
Khaldoun Darwich,
Amirah Alnour,
Marwan Al-Raeei,
Chadi Azmeh

摘要

Background

Bone defects are a frequent challenge in dental practices, and their reconstruction poses significant difficulties within orthopedic treatment. This study delves into the potential of methylsulfonylmethane (MSM), known for its osteoinductive properties, to promote bone healing in bony defects created in the mandibles of rabbits.

Materials and Methods

We discussed an experimental study involving twelve male New Zealand rabbits, each subjected to four surgically induced defects in their mandibles. These defects were organized into four groups: two experimental groups and two control groups. In the experimental setup, one set of defects was treated with Gelfoam and a 20 mM concentration of MSM, while another received Gelfoam with a 10 mM concentration of MSM. The control groups consisted of one filled with Gelfoam alone (positive control) and another that was left to heal naturally (negative control). We assessed the bone repair histologically after euthanizing the rabbits at three different time points: 4, 8, and 12 weeks post-surgery, analyzing four rabbits at each time interval.

Results of Study

The results revealed significant differences in osteoblast cell activity between the MSM-treated groups compared to the Gelfoam and control groups (p < 0.001 for both concentrations, p = 0.038 for 10 mM, and p = 0.013 for 20 mM). Notably, the comparison between the two MSM groups showed further statistical significance (p = 0.004). However, there were no significant differences between the Gelfoam alone and the control groups (p = 0.468). Additionally, the degree of osteoid tissue formation was significantly greater in the MSM groups compared to Gelfoam and control groups (p = 0.021 for 20 mM, p = 0.028 for 10 mM, both p < 0.05 for other comparisons). Again, there were no significant differences between the Gelfoam and control groups (p = 0.854).

Conclusion

As a result, the study demonstrates that the topical application of methylsulfonylmethane (MSM) serves as an effective therapeutic approach to enhance bone formation and expedite the healing of bone defects in rabbits. These findings hold considerable implications for oral oncology, where the regeneration of bone structure is crucial for patient recovery and improved outcomes in dental and maxillofacial treatments.