Background <p>Rehabilitation of a single missing tooth using a dental implant, although often considered less complex, presents unique clinical challenges and limitations. Central to successful outcomes is a prosthetically driven treatment approach, wherein the final crown position dictates the ideal implant placement within the alveolar bone.</p> Treatment Considerations <p>Comprehensive treatment planning requires integrating findings from clinical, radiographic, and diagnostic evaluations to assess site suitability and anatomical constraints. Multiple factors influence implant planning, including soft tissue parameters such as gingival biotype, hard tissue factors like bone quality and quantity, proximity to anatomical structures, and the condition of adjacent and opposing dentition. Importantly, different regions of the oral cavity present distinct priorities: Esthetic demands dominate in the maxillary anterior region, whereas occlusal loads and biomechanical considerations are paramount in posterior sites. Recognizing the regional variability in planning criteria is essential for clinicians to ensure ideal implant positioning, long-term osseointegration, and esthetic success.</p> Discussion <p>This review consolidates and organizes key factors that vary by anatomical region, offering a structured framework to support evidence-based decision-making in single-tooth implant rehabilitation. Additionally, we outline the commonly employed surgical protocols, highlighting how clinical and anatomical variables guide the selection of one-stage vs. two-stage placement, immediate vs. delayed loading, and other procedural variations. By emphasizing both universal principles and site-specific considerations, this article aims to serve as a practical guide for clinicians striving for predictable and patient-centered single-tooth implant outcomes.</p>