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<p>Tissue engineering is a new alternative for the treatment of severe mandibular defects,due to its low morbidity and predictability. Specifically, the use of adipose-derived stemcells (ADSc) combined with ceramic substitute like β-TCP. A male patient comesprivate clinic of Rodrigo Fariña, due to slow-growing and asymptomatic right facialasymmetry. The CT shows a unilocular radiolucent area of 6 cm in its longest axis withdefined borders causing rizalysis of adjacent teeth in the right mandibular body.Histopathological examination after incisional biopsy, it´s diagnoses was plexiformunicystic ameloblastoma. Prior to surgical intervention, abdominal adipose tissue wascollected for culture with osteoinductive media, in this case ascorbic acid anddexamethasone co-cultivated with blocks of β-TCP. One months later, the mandibularsegmental resection with a safety edge is performed where, in the same surgical act,the combination of ADSc and the β-TCP is placed on a titanium mesh at the resectionsite. Six months later, a biopsy is performed that corroborates the bone neoformationwhere it is decided to carry out dental rehabilitation on osseointegrated implants. Thecombination of biomaterials in conjunction with ADSc allows an effective therapy, witha good prognosis for the treatment of severe mandibular defects caused by benignneoplasms.</p>

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Mandibular Defect Reconstruction Using Tissue Engineering: Case Report and Long-Term Follow-Up

  • 期刊论文

  • 发表日期：

    2025年6月22日

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  • Rodrigo Fariña,
  • Jorge Lolas,
  • Emilio Moreno,
  • Felipe Soto,
  • Pablo Romero-Araya

摘要

Tissue engineering is a new alternative for the treatment of severe mandibular defects,due to its low morbidity and predictability. Specifically, the use of adipose-derived stemcells (ADSc) combined with ceramic substitute like β-TCP. A male patient comesprivate clinic of Rodrigo Fariña, due to slow-growing and asymptomatic right facialasymmetry. The CT shows a unilocular radiolucent area of 6 cm in its longest axis withdefined borders causing rizalysis of adjacent teeth in the right mandibular body.Histopathological examination after incisional biopsy, it´s diagnoses was plexiformunicystic ameloblastoma. Prior to surgical intervention, abdominal adipose tissue wascollected for culture with osteoinductive media, in this case ascorbic acid anddexamethasone co-cultivated with blocks of β-TCP. One months later, the mandibularsegmental resection with a safety edge is performed where, in the same surgical act,the combination of ADSc and the β-TCP is placed on a titanium mesh at the resectionsite. Six months later, a biopsy is performed that corroborates the bone neoformationwhere it is decided to carry out dental rehabilitation on osseointegrated implants. Thecombination of biomaterials in conjunction with ADSc allows an effective therapy, witha good prognosis for the treatment of severe mandibular defects caused by benignneoplasms.