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Background <p>Plasma cells are antibody producing ovoid cells which are generated secondary to antigenic stimulation of B-cells. In case of plasma cell dyscrasias, these cells virtually always secrete monoclonal immunoglobulins (Ig) or Ig fragments, serving as tumour markers. A degree of overlap in their histological and immunological characteristic raises a diagnostic dilemma.</p> Objective <p>To report the distribution of plasma cell lesions encountered in the oral cavity and discuss the diagnostic difficulty of plasma cell lesions.</p> Material and methods <p>This retrospective study was conducted on plasma cell lesions encountered over a period of 13-year (January 2011 to August 2023) analysis.</p> Results <p>Out of 5068 biopsies, 20(0.39%) cases were diagnosed with plasma cell lesions. Out of which 14 were plasma cell gingivitis (PCG), 1 plasma cell granuloma, 2 multiple myeloma (MM), 2 solitary plasmacytoma of bone (SP) and 1 case of IgG4-related disorder.</p> Conclusion <p>For better management and treatment plan formulation, distinction of reactive or immune-mediated from neoplastic plasma cells lesions is of utmost importance. The study further helped in eliminating the benign from the malignant lesions serves as the basis for determining prognosis.</p>

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Unveiling the Mysterious Plasma Cell Lesions of Oral Cavity: A 13-year Institutional Experience

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Akanksha Gupta,
  • Anju Devi,
  • Anjali Narwal,
  • Mala Kamboj

摘要

Background

Plasma cells are antibody producing ovoid cells which are generated secondary to antigenic stimulation of B-cells. In case of plasma cell dyscrasias, these cells virtually always secrete monoclonal immunoglobulins (Ig) or Ig fragments, serving as tumour markers. A degree of overlap in their histological and immunological characteristic raises a diagnostic dilemma.

Objective

To report the distribution of plasma cell lesions encountered in the oral cavity and discuss the diagnostic difficulty of plasma cell lesions.

Material and methods

This retrospective study was conducted on plasma cell lesions encountered over a period of 13-year (January 2011 to August 2023) analysis.

Results

Out of 5068 biopsies, 20(0.39%) cases were diagnosed with plasma cell lesions. Out of which 14 were plasma cell gingivitis (PCG), 1 plasma cell granuloma, 2 multiple myeloma (MM), 2 solitary plasmacytoma of bone (SP) and 1 case of IgG4-related disorder.

Conclusion

For better management and treatment plan formulation, distinction of reactive or immune-mediated from neoplastic plasma cells lesions is of utmost importance. The study further helped in eliminating the benign from the malignant lesions serves as the basis for determining prognosis.