Aim <p>This study aimed to evaluate the efficacy of cyanoacrylate tissue adhesive (PeriAcryl90 High Viscosity) for intraoral wound closure.</p> Methods <p>Subjects undergoing minor oral surgical procedures such as extractions, canine exposure, surgical removal of impacted teeth, alveoloplasty, biopsy, and mucocele excision were included in the study. The study setting was the outpatient department, and the study design was a single-arm clinical study. Wound closure was performed using cyanoacrylate tissue adhesive. The patients were followed up for 7 postoperative days. The time of application of the tissue adhesive, bondage of adhesive to the tissue surface, signs of inflammation in relation to cyanoacrylate, allergic reaction, and wound dehiscence were evaluated.</p> Results <p>Fifty participants completed the study. The mean application time in seconds was 233.84&#xa0;s. There was no significant inflammatory or allergic response to the cyanoacrylate adhesive at the surgical test site. Only three of 50 subjects reported wound dehiscence, but healing occurred uneventfully by the end of one week.</p> Conclusions <p>Cyanoacrylate tissue adhesive can be safely used in minor oral surgeries as a method of closure, with high patient satisfaction and compliance. The routine use of tissue adhesives in daily practice in the surgical field is limited by unawareness, conventional beliefs, and the high cost of the adhesive material itself.</p>