<p>Maximum dental procedures are carried out under local anesthesia. Scarce literature exists about the ophthalmic complications of after intraoral regional anesthesia. In this case report, authors report a case of 58-year-old female patient reporting to the department with chief complaint of pain in decayed tooth in maxilla. On examination, grossly carious maxillary left second premolar was present. Patient experienced diplopia in relation to contralateral eye (right eye), immediately after giving local anesthesia (anterior superior alveolar nerve block and greater palatine nerve block). Other ophthalmic complications like eye movements restriction were not observed. No abnormal eye signs were noticed in ipsilateral eye (left). Patient was anxious and was counseled about the temporary nature of the symptom. The patient was kept under observation, and vitals were stable. Diplopia resolved in 90 min. The specific aim of the case report is to present a rare ophthalmic complication of contralateral diplopia after giving regional block and its management. Although rare, ophthalmological complications are distressful for the patient following intraoral regional blocks. The clinicians should be aware of the ophthalmic complications, associated signs and symptoms, its pathophysiology and psychological impact on the patient. Knowing all this is mandatory to provide best care to the patient. Patient counseling and reassurance play an important role in management of rare ophthalmic complications.</p>