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Background <p>A&#xa0;new coronavirus emerged in late 2019 and spread rapidly around the globe, leading the World Health Organization to declare COVID-19 a&#xa0;pandemic. Vaccines were developed that helped to reduce severe outcomes, but ongoing variants highlight the need for complementary methods to decrease morbidity and mortality.</p> Objective <p>To explore and compare the effect of aerobic versus resistance training on immune system markers, COVID-19 severity, and disease progression during COVID-19 infection.</p> Design <p>Randomized study.</p> Participants <p>The study included 38 participants with mild–moderate COVID-19, aged 24–45&#xa0;years. Participants were randomly assigned to two groups: an aerobic exercise group and a&#xa0;resistance training group. The dependent variables were immune biomarkers and respiratory symptom severity.</p> Interventions <p>The interventions comprised moderate-intensity anaerobic or aerobic exercise for 2&#xa0;weeks (40 min/session, 3&#xa0;sessions/week).</p> Results <p>There were no significant differences in immune biomarkers and respiratory symptom severity between the groups (<i>p</i> &gt; 0.05). The severity of respiratory symptoms decreased significantly in the aerobic exercise group after 2&#xa0;weeks of exercise, while immune biomarkers increased significantly in the aerobic exercise group after 2&#xa0;weeks of exercise (<i>p</i> &lt; 0.05).</p> Conclusion <p>The current study found that 2&#xa0;weeks of moderate-intensity aerobic exercise was more effective in mitigating the severity and progression of COVID-19 symptoms, potentially increasing immune function.</p>

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Aerobic versus resistance training and immune biomarkers in mild-to-moderate COVID 19: a randomized trial

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Motaz Alawna,
  • Ayman A. Mohamed,
  • Tamara Rizqallah

摘要

Background

A new coronavirus emerged in late 2019 and spread rapidly around the globe, leading the World Health Organization to declare COVID-19 a pandemic. Vaccines were developed that helped to reduce severe outcomes, but ongoing variants highlight the need for complementary methods to decrease morbidity and mortality.

Objective

To explore and compare the effect of aerobic versus resistance training on immune system markers, COVID-19 severity, and disease progression during COVID-19 infection.

Design

Randomized study.

Participants

The study included 38 participants with mild–moderate COVID-19, aged 24–45 years. Participants were randomly assigned to two groups: an aerobic exercise group and a resistance training group. The dependent variables were immune biomarkers and respiratory symptom severity.

Interventions

The interventions comprised moderate-intensity anaerobic or aerobic exercise for 2 weeks (40 min/session, 3 sessions/week).

Results

There were no significant differences in immune biomarkers and respiratory symptom severity between the groups (p > 0.05). The severity of respiratory symptoms decreased significantly in the aerobic exercise group after 2 weeks of exercise, while immune biomarkers increased significantly in the aerobic exercise group after 2 weeks of exercise (p < 0.05).

Conclusion

The current study found that 2 weeks of moderate-intensity aerobic exercise was more effective in mitigating the severity and progression of COVID-19 symptoms, potentially increasing immune function.