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<p>1,2-Propanediol (1,2-PD) is a valuable industrial chemical and a potential biofuel. It has attracted significant interest due to its wide range of pharmaceutical and industrial applications. The industrial-scale production of 1,2-PD by wild bacterial strains is restricted by low concentrations and the increased time the bacterium takes to reach maximum concentration. In the present study, <i>Brucella oryzae</i> isolated from chicken manure-contaminated soil samples efficiently converted glycerol to 1,2-PD. This isolated strain, the first-ever bacterium from the <i>Brucella</i> genus to produce 1,2-PD, is significant. The time-dependent growth analysis revealed the maximum 1,2-PD production at 72&#xa0;h. Further, the growth and 1,2-PD production at various concentrations of glycerol (carbon source) and ammonium sulphate (nitrogen source) was investigated, producing a maximum concentration of 50.19&#xa0;g/L. The production of 1,2-PD by <i>Brucella oryzae</i> within 72&#xa0;h of growth in the production media was not reported, further highlighting its novelty. This is the first study on 1,2-PD production using <i>Brucella oryzae</i>, demonstrating its potential as a natural producer of 1,2-PD.</p> Graphical Abstract <p></p>

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Sustainable Microbial Conversion of Glycerol to 1,2-Propanediol by Brucella oryzae: Advancing Bio-Based Chemical Synthesis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月21日

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  • Deepak Prabhu,
  • Ashutosh Kotian,
  • Raghavendra Paduvari,
  • Akshatha Vatedka,
  • Divyashree Somashekara

摘要

1,2-Propanediol (1,2-PD) is a valuable industrial chemical and a potential biofuel. It has attracted significant interest due to its wide range of pharmaceutical and industrial applications. The industrial-scale production of 1,2-PD by wild bacterial strains is restricted by low concentrations and the increased time the bacterium takes to reach maximum concentration. In the present study, Brucella oryzae isolated from chicken manure-contaminated soil samples efficiently converted glycerol to 1,2-PD. This isolated strain, the first-ever bacterium from the Brucella genus to produce 1,2-PD, is significant. The time-dependent growth analysis revealed the maximum 1,2-PD production at 72 h. Further, the growth and 1,2-PD production at various concentrations of glycerol (carbon source) and ammonium sulphate (nitrogen source) was investigated, producing a maximum concentration of 50.19 g/L. The production of 1,2-PD by Brucella oryzae within 72 h of growth in the production media was not reported, further highlighting its novelty. This is the first study on 1,2-PD production using Brucella oryzae, demonstrating its potential as a natural producer of 1,2-PD.

Graphical Abstract