<p>Dysbiosis of gut microbiota is the primary cause of several diseases. Current treatment procedures have several side effects. Therefore, there is a great need to develop alternative treatment strategies for the prevention and treatment of diseases. A recent study conducted on low-methylated pectin (LMP), derived from citrus waste displayed unique functional attributes. In this regard LMP, a soluble dietary fiber extracted from citrus peel, has attracted considerable attention because of its potential to influence gut microflora and support systemic health. LMPs derived from <i>citrus</i> peel waste are exclusively fermented by gut microbiota such as <i>Bacteroides</i> and <i>Bifidobacterium</i> species to produce short-chain fatty acids, which confer beneficial effect on host health. Thus, it has anti-inflammatory, intestinal permeability-reducing, and gut barrier integrity-promoting properties. LMPs help in the treatment of metabolic diseases such as diabetes and obesity. This review discusses recent technological advancements in the extraction and purification methods used in the production of LMPs from citrus peel waste. It also highlights the recent functional attributes of different LMPs in regulating the gut and other metabolic disorders. Thus, LMPs hold great potential as nutraceutical compounds for the treatment and prevention of various diseases.</p> Graphical Abstract <p></p>