Scholarlink

<p>The current research work deals with the eco-friendly production of silver nanoparticles (AgNPs) using the aqueous leaf extract of <i>Araucaria excelsa</i>. Furthermore, biomedical significance of AgNPs was assessed particularly in the areas of anticancer, antioxidant, and antidiabetic applications. The adoption of this environmentally friendly technique overcomes the disadvantages of traditional chemical synthesis by employing phytochemicals as the natural reducing and stabilizing agents, thus reducing the toxicity and environmental impact to a great extent. The AgNPs obtained through biosynthesis were characterized by a series of techniques like UV-Vis spectroscopy, FTIR spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD) for their formation, stability, and crystalline morphology. The UV-Vis spectrum showed a strong peak of surface plasmon resonance at 420&#xa0;nm, whereas SEM images showed nanoparticles that were spherical and uniformly dispersed with an average size of 28.32&#xa0;nm, which is an indication of successful nanoparticle synthesis. Assessments based on biological factors showed that the A. excelsa-derived AgNPs are very effective, having an antioxidant activity of 53.19%, a strong α-glucosidase inhibition of 64.42%, and also impressive cytotoxicity of 52.01% against human HepG2 cells, thus confirming their medicinal properties against stress, diabetes, and cancer spread. The indicated anticancer activities are due to the plant-derived bioactive molecules’ synergistic interaction which leads to an increase in the generation of reactive oxygen species and consequently the death of cancer cells. With this, <i>A. excelsa</i>-mediated AgNPs become the best choice for a nanoplatform that is easy to produce, biocompatible, and also sustainable for biomedical applications. Future studies are needed to clarify anticancer mechanisms at the molecular level, perform in vivo safety evaluations, and also look into the translational prospects of these green-synthesized nanoparticles in targeted cancer therapy and drug delivery.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Valorization of Araucaria Excelsa Extract for Synthesis of Silver Nanoparticles and their Potential Anticancer Properties

  • 期刊论文

  • 发表日期：

    2025年11月21日

查看全文
  • Eisha Javed,
  • Muhammad Zubair,
  • Suliman Mohammed Suliman Alghanem,
  • Faiza Batool,
  • Tayyaba Shaheen,
  • Haifa Abdul Aziz Sakit Alhaithloul,
  • Muhammad Bilal Khan Niazi,
  • Muhammad Rizwan

摘要

The current research work deals with the eco-friendly production of silver nanoparticles (AgNPs) using the aqueous leaf extract of Araucaria excelsa. Furthermore, biomedical significance of AgNPs was assessed particularly in the areas of anticancer, antioxidant, and antidiabetic applications. The adoption of this environmentally friendly technique overcomes the disadvantages of traditional chemical synthesis by employing phytochemicals as the natural reducing and stabilizing agents, thus reducing the toxicity and environmental impact to a great extent. The AgNPs obtained through biosynthesis were characterized by a series of techniques like UV-Vis spectroscopy, FTIR spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD) for their formation, stability, and crystalline morphology. The UV-Vis spectrum showed a strong peak of surface plasmon resonance at 420 nm, whereas SEM images showed nanoparticles that were spherical and uniformly dispersed with an average size of 28.32 nm, which is an indication of successful nanoparticle synthesis. Assessments based on biological factors showed that the A. excelsa-derived AgNPs are very effective, having an antioxidant activity of 53.19%, a strong α-glucosidase inhibition of 64.42%, and also impressive cytotoxicity of 52.01% against human HepG2 cells, thus confirming their medicinal properties against stress, diabetes, and cancer spread. The indicated anticancer activities are due to the plant-derived bioactive molecules’ synergistic interaction which leads to an increase in the generation of reactive oxygen species and consequently the death of cancer cells. With this, A. excelsa-mediated AgNPs become the best choice for a nanoplatform that is easy to produce, biocompatible, and also sustainable for biomedical applications. Future studies are needed to clarify anticancer mechanisms at the molecular level, perform in vivo safety evaluations, and also look into the translational prospects of these green-synthesized nanoparticles in targeted cancer therapy and drug delivery.