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<p>Diabetes Mellitus currently affects more than 700&#xa0;million individuals globally, with 18.6&#xa0;million suffering annually from diabetic foot ulcers - conditions that significantly raise the risk of limb amputation and mortality. The treatment remains a challenge due to delayed wound healing and intricate cell-level healing processes. This research investigates the sustainable use of hydrolysate, a by-product from <i>Kigelia africana (K. africana)</i> fiber extraction, as a functional component in wound dressings. The key findings reveal the presence of phytochemicals like flavonoids, sterols, saponins, and cardiac glycosides in the hydrolysate demonstrating notable bioactivity, including 74.49% antioxidant potential, 84.51% hemolysis inhibition, and 52.47% α-amylase suppression. FTIR and SEM analyses validated the successful adherence of hydrolysate onto bamboo dressing materials. Antimicrobial evaluation revealed effective inhibition against <i>K. pneumoniae</i> (32&#xa0;mm), <i>A. lwoffii</i> (26&#xa0;mm), <i>S. aureus</i> (41&#xa0;mm), and <i>S. epidermidis</i> (46&#xa0;mm). The brine shrimp toxicity assay upraised the nontoxic nature of the hydrolysate within the fourfold of the MIC (50&#xa0;mg/mL) and the wound scratch assay elucidated 55% closure within 24&#xa0;h. These findings highlight the potential of the hydrolysate as a sustainable, plant-based bioactive material for effective wound care.</p>

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Invitro Investigation for Valorization of Kigelia africana (Lam.) Benth. Fruit Fibre Extraction Hydrolysate as a Potential Bioactive Finishing Agent for Diabetic Foot Ulcer Wound Dressing

  • 期刊论文

  • 发表日期：

    2025年7月10日

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  • Manimozhi Gomathi,
  • Natarajan Vasugi

摘要

Diabetes Mellitus currently affects more than 700 million individuals globally, with 18.6 million suffering annually from diabetic foot ulcers - conditions that significantly raise the risk of limb amputation and mortality. The treatment remains a challenge due to delayed wound healing and intricate cell-level healing processes. This research investigates the sustainable use of hydrolysate, a by-product from Kigelia africana (K. africana) fiber extraction, as a functional component in wound dressings. The key findings reveal the presence of phytochemicals like flavonoids, sterols, saponins, and cardiac glycosides in the hydrolysate demonstrating notable bioactivity, including 74.49% antioxidant potential, 84.51% hemolysis inhibition, and 52.47% α-amylase suppression. FTIR and SEM analyses validated the successful adherence of hydrolysate onto bamboo dressing materials. Antimicrobial evaluation revealed effective inhibition against K. pneumoniae (32 mm), A. lwoffii (26 mm), S. aureus (41 mm), and S. epidermidis (46 mm). The brine shrimp toxicity assay upraised the nontoxic nature of the hydrolysate within the fourfold of the MIC (50 mg/mL) and the wound scratch assay elucidated 55% closure within 24 h. These findings highlight the potential of the hydrolysate as a sustainable, plant-based bioactive material for effective wound care.