<p>Radionuclides have been used for therapeutic purposes for more than a hundred years. A few radionuclides, such as copper-64 (⁶⁴Cu), palladium-103 (¹⁰³ Pa), iodine-124,125 (^124,125I), ytterbium-169 (¹⁶⁹Yb), rhenium-186 (¹⁸⁶Re), and iridium-192 (¹⁹²Ir) are successfully used for the treatment of many diseases. Therefore, the production of these radioisotopes is of great importance in applied physics. The aim of this study is to investigate the effects of different deuteron optical models on the cross-section calculations of deuteron induced reactions on some therapeutic radionuclides. In this study, the cross sections of deuteron-induced reaction on these radioisotopes is calculated using five deuteron optical models with the latest version of TALYS computer code and compared with the available experimental data taken from Experimental Nuclear Reaction Data (EXFOR) library. Deuteron optical model potentials are available as an optional input in TALYS code. Graphs and quantitative analyses are used to present the findings and interpretations of the results. In the reactions studied, the peaks observed in the experimental data are well reproduced by the theoretical calculations.</p>