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<p>Cervical cancer presents considerable public health issues, particularly in its advanced stages, which require the implementation of effective management strategies. The role of radiation therapy in treatment is vital, highlighting the necessity for enhanced delivery techniques. We retrospectiveselected 15 patients with cervical cancer in FIGO stages IIB to IVA. 3DCRT, IMRT and Rapid Arc plans were compared in terms of target, organs at risk (OARs), conformity index (CI), uniformity index (UI), homogeneity index (HI), grandient index (GI), uniformity dosimetry index (UDI), conformation number (CN) and also recorded eclipse gradient index (GM), the high dose spillage index (outside the PTV) and the dose spillage index (R50%), the number of monitor units (MUs). Both IMRT and Rapid Arc demonstrated significantly better conformity (CN: 0.91 ± 0.012, 0.92 ± 0.002) compared to 3D-CRT (CN: 0.62 ± 0.037; <i>p</i> &lt; 0.001). Rapid Arc not only minimized dose spillage (R50%: 2.91 ± 0.18) but also required fewer monitor units (MU: 578.15 ± 40.27) than IMRT (MU: 1595.7 ± 119.41). Both techniques provided enhanced organ-at-risk (OAR) sparing relative to 3D-CRT, particularly in reducing doses to the bladder and rectum (<i>p</i> &lt; 0.001). Rapid Arc further decreased doses to the femoral head and bowel, highlighting its effectiveness in controlling spillage, improving dose gradient, and achieving overall dose conformity. Both Rapid Arc and IMRT improved dose conformity and provided better protection of organs at risk compared to 3D-CRT. Rapid Arc offered the most effective control over dose spillage, required fewer monitor units, and is an effective option for ensuring optimal target coverage while reducing doses to the OARs.</p>

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Dosimetric Comparison of 3DCRT, IMRT, and Rapid Arc Treatment Techniques in Cervical Cancer: Evaluating Plan Quality and Organ at Risk Sparing

  • 期刊论文

  • 发表日期：

    2025年2月5日

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  • Deepali Bhaskar Patil,
  • Mukesh Kumar Zope,
  • Devraj Singh

摘要

Cervical cancer presents considerable public health issues, particularly in its advanced stages, which require the implementation of effective management strategies. The role of radiation therapy in treatment is vital, highlighting the necessity for enhanced delivery techniques. We retrospectiveselected 15 patients with cervical cancer in FIGO stages IIB to IVA. 3DCRT, IMRT and Rapid Arc plans were compared in terms of target, organs at risk (OARs), conformity index (CI), uniformity index (UI), homogeneity index (HI), grandient index (GI), uniformity dosimetry index (UDI), conformation number (CN) and also recorded eclipse gradient index (GM), the high dose spillage index (outside the PTV) and the dose spillage index (R50%), the number of monitor units (MUs). Both IMRT and Rapid Arc demonstrated significantly better conformity (CN: 0.91 ± 0.012, 0.92 ± 0.002) compared to 3D-CRT (CN: 0.62 ± 0.037; p < 0.001). Rapid Arc not only minimized dose spillage (R50%: 2.91 ± 0.18) but also required fewer monitor units (MU: 578.15 ± 40.27) than IMRT (MU: 1595.7 ± 119.41). Both techniques provided enhanced organ-at-risk (OAR) sparing relative to 3D-CRT, particularly in reducing doses to the bladder and rectum (p < 0.001). Rapid Arc further decreased doses to the femoral head and bowel, highlighting its effectiveness in controlling spillage, improving dose gradient, and achieving overall dose conformity. Both Rapid Arc and IMRT improved dose conformity and provided better protection of organs at risk compared to 3D-CRT. Rapid Arc offered the most effective control over dose spillage, required fewer monitor units, and is an effective option for ensuring optimal target coverage while reducing doses to the OARs.