Scholarlink

<p>This study examines the impact of antiretroviral therapy (ART) adherence on visceral leishmaniasis (VL) relapse among 90 HIV–VL co-infected patients in Bihar, India, using the Hindi version of the MMAS-8 to assess adherence. Overall, 21.1% experienced VL relapse, with the highest relapse in the low-adherence group (36.1%) versus medium (28.6%) and high (8.5%). Logistic regression indicates that low adherence confers an approximately sixfold increase in relapse risk. The findings suggest that consistent adherence to ART significantly supports immune recovery, as reflected by the restoration of CD4<sup>+</sup> T-cell counts, thereby reducing the risk of VL relapse. The work underscores the critical role of ART adherence in mitigating VL relapse among HIV-co-infected patients, a group with substantial morbidity and mortality risk. Poor adherence compromises immune reconstitution, especially when CD4<sup>+</sup> T-cell counts fall below 100 cells/mm<sup>3</sup>, increasing relapse vulnerability. As a study conducted in an Indian endemic setting, it highlights the need for targeted adherence interventions, counselling, and support systems to optimize outcomes and reduce disease burden in resource-limited regions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of anti-retroviral therapy adherence on relapse of visceral leishmaniasis among HIV-VL co-infected patients

  • 期刊论文

  • 发表日期：

    2026年3月7日

查看全文
  • Ram Pund,
  • Gopal Vishwas,
  • Krishna Pandey,
  • Sameer Dhingra

摘要

This study examines the impact of antiretroviral therapy (ART) adherence on visceral leishmaniasis (VL) relapse among 90 HIV–VL co-infected patients in Bihar, India, using the Hindi version of the MMAS-8 to assess adherence. Overall, 21.1% experienced VL relapse, with the highest relapse in the low-adherence group (36.1%) versus medium (28.6%) and high (8.5%). Logistic regression indicates that low adherence confers an approximately sixfold increase in relapse risk. The findings suggest that consistent adherence to ART significantly supports immune recovery, as reflected by the restoration of CD4+ T-cell counts, thereby reducing the risk of VL relapse. The work underscores the critical role of ART adherence in mitigating VL relapse among HIV-co-infected patients, a group with substantial morbidity and mortality risk. Poor adherence compromises immune reconstitution, especially when CD4+ T-cell counts fall below 100 cells/mm3, increasing relapse vulnerability. As a study conducted in an Indian endemic setting, it highlights the need for targeted adherence interventions, counselling, and support systems to optimize outcomes and reduce disease burden in resource-limited regions.