<p>Cancer is undoubtedly one of the most notorious diseases in the history of mankind. With an epidemiological data approximating almost 10 million deaths in 2020, it stands out to be the second leading cause of death—only after cardiovascular diseases. There are several reported and unreported causes that might lead to cancer. Parasites are classified as one of the pro-carcinogenic agents. However, we have also to keep in mind that, in the light of evolution, the parasites won’t allow the host to die out, but inadvertently becomes the cause of their death too. Keeping this in mind, this review-article targets the anti-proliferative effects of <i>Trypanosoma cruzi,</i> to identify the factors by virtue of which they can exert control on the oncogenes. Induction of apoptosis, enhanced immune response, prevention of metastasis and angiogenesis, reduction of proliferative signals, and control of inflammatory responses are some of the positive effects of parasite infections on tumourigenesis recorded so far. The aim of this review is to study the factors, significantly produced by <i>T. cruzi</i> and the mechanism of their action, by virtue of which the expression of oncogenes can decrease.</p> Graphical abstract <p></p>