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<p>A sol–gel method created a nano-sized bismuth oxide bioglass doped with iron oxide. Immersing samples in simulated body fluid (SBF) for different times assessed bioactivity in vitro. Bioglass was characterized using XRD, FTIR, Iron-57 Mössbauer, SEM, EDX, and DLS. In iron-rich samples, especially those with higher iron concentrations, Fe ions infiltrated the glass matrix faster than Si ions. Osteoblast-like MC3T3-E1 cells, especially those with iron adhered to bioactive glass (BAG), when co-cultivated. The material may be used in thermoseeds for targeted drug delivery or osteogenesis.</p>

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Advanced Structural Modification in Bismuth-Based Nano-Bioactive Glass: The Effect of Iron Oxide on Biocompatibility Enhancement

  • 期刊论文

  • 发表日期：

    2026年8月5日

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  • Mahmoud A. Kenawy,
  • M. A. Abu Ghazala,
  • Taha M. Tiama,
  • Ayman S. El Shinawy,
  • H. H. El-Bahnasawy

摘要

A sol–gel method created a nano-sized bismuth oxide bioglass doped with iron oxide. Immersing samples in simulated body fluid (SBF) for different times assessed bioactivity in vitro. Bioglass was characterized using XRD, FTIR, Iron-57 Mössbauer, SEM, EDX, and DLS. In iron-rich samples, especially those with higher iron concentrations, Fe ions infiltrated the glass matrix faster than Si ions. Osteoblast-like MC3T3-E1 cells, especially those with iron adhered to bioactive glass (BAG), when co-cultivated. The material may be used in thermoseeds for targeted drug delivery or osteogenesis.