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<p>This study explores the intriguing interaction between 1-(4-bromobenzyl)-2-(4-bromophenyl)-4-fluoro-1H-benzo[d]imidazole (BBFB) and silicon dioxide (SiO<sub>2</sub>) nanoparticles, unveiling how functionalization enhances both the photophysical properties and antimicrobial efficacy of BBFB. Through absorption, fluorescence, and FT-IR spectroscopy, it is revealed that BBFB undergoes strong adsorption onto the surface of SiO<sub>2</sub>nanoparticles, primarily driven by electron transfer interactions. The fluorescence quenching observed in BBFB is attributed to photo-induced electron transfer from the excited state of BBFB to the conduction band of SiO<sub>2</sub> nanoparticles. Functionalization of BBFB with SiO<sub>2</sub> nanoparticles significantly enhances its biocidal activity. Antibacterial assays indicate that the BBFB-functionalized SiO<sub>2</sub> nanoparticles exhibit superior efficacy against <i>Staphylococcus aureus</i> and <i>Salmonella typhi</i>, compared to unmodified BBFB. In antifungal testing, BBFB-functionalized SiO<sub>2</sub> nanoparticles also demonstrate improved performance against <i>Aspergillus flavus</i> and <i>Candida albicans</i>. The study highlights the potential of BBFB-functionalized SiO<sub>2</sub> nanoparticles as a promising antimicrobial agent, offering enhanced biological activity, reduced reaction times in synthesis, and improved efficiency, thus presenting a viable, eco-friendly alternative for various pharmaceutical applications.</p>

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Silicon Dioxide Functionalized with Benzimidazole: A Versatile Dual-Function Sensor and Enhanced Antimicrobial Agent

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • HaoTang,
  • Xue Xia,
  • Kanagaraj Rajalakshmi,
  • Jian Shen,
  • K. Jayamoorthy,
  • Selvaraj Muthusamy,
  • Dongwei Zhu,
  • Xiaojian Liu,
  • R. Sasikala

摘要

This study explores the intriguing interaction between 1-(4-bromobenzyl)-2-(4-bromophenyl)-4-fluoro-1H-benzo[d]imidazole (BBFB) and silicon dioxide (SiO2) nanoparticles, unveiling how functionalization enhances both the photophysical properties and antimicrobial efficacy of BBFB. Through absorption, fluorescence, and FT-IR spectroscopy, it is revealed that BBFB undergoes strong adsorption onto the surface of SiO2nanoparticles, primarily driven by electron transfer interactions. The fluorescence quenching observed in BBFB is attributed to photo-induced electron transfer from the excited state of BBFB to the conduction band of SiO2 nanoparticles. Functionalization of BBFB with SiO2 nanoparticles significantly enhances its biocidal activity. Antibacterial assays indicate that the BBFB-functionalized SiO2 nanoparticles exhibit superior efficacy against Staphylococcus aureus and Salmonella typhi, compared to unmodified BBFB. In antifungal testing, BBFB-functionalized SiO2 nanoparticles also demonstrate improved performance against Aspergillus flavus and Candida albicans. The study highlights the potential of BBFB-functionalized SiO2 nanoparticles as a promising antimicrobial agent, offering enhanced biological activity, reduced reaction times in synthesis, and improved efficiency, thus presenting a viable, eco-friendly alternative for various pharmaceutical applications.