<p>Silicon based biosensors have emerged as a promising solution for real-time virus detection due to their high sensitivity and scalability. A new Triple Material Gate Nanosheet (TMGNS) MOSFETs-based biosensor for extremely sensitive SARS-CoV-2 detection is presented in this work for the first time. The suggested TMGNS MOSFETs enhances detection sensitivity and charge modulation by utilizing the special benefits of nanosheet MOSFETs, including improved electrostatic control, a high surface-to-volume ratio, and decreased short-channel effects. In this work, the S-protein and complementary DNA (c-DNA) of SARS-CoV-2 are two viral biomarkers that may be precisely detected. The device's exceptional performance is confirmed by Technology Computer-Aided Design (TCAD) simulations, which show notable threshold voltage shifts and drain current modulation in response to changes in the dielectric constant of biomolecules. The proposed biosensor has a quick response time of 4&#xa0;ps and a high drain current sensitivity of 3.5 × 10⁶ at k = 12. It is appropriate for real-time viral detection due to its 10% improvement in the I_ON/I_OFF ratio and 6% improvement in subthreshold swing. Additionally, robust performance is confirmed by sensitivity analysis under various biomolecular charge densities, with a 22% improvement in threshold voltage for k = 12. A scalable, low-power, and highly effective method for identifying SARS-CoV-2 and other emerging viruses, the silicon based TMGNS MOSFETs is positioned as a prospective contender for next-generation point-of-care diagnostic applications due to its improved electrostatic coupling and charge sensing capabilities.</p>