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Purpose of the Review <p>Radiotherapy for malignancies within the chest improves oncologic outcomes but may increase the risk of cardiovascular disease, particularly coronary artery disease. Coronary artery calcifications (CAC) are a validated marker of coronary disease and can be readily identified on routine computed tomography scans used for radiotherapy planning and follow-up. However, its relevance in radiation oncology remains underrecognized.</p> Recent Findings <p>In this review, we examine the evidence supporting CAC identified on radiotherapy planning imaging as a prognostic marker of cardiovascular events. We then discuss how radiation may exacerbate the progression of CAC observed after radiation treatment. Finally, we discuss how considering radiation dose to the heart in the context of CAC may further strengthen our ability to predict cardiovascular outcomes.</p> Summary <p>Recognizing CAC both as a pre-existing risk factor for cardiovascular morbidity and a clinically relevant endpoint impacted by radiotherapy is essential to understanding its implementation into clinical practice to advance the personalization of cardio-oncologic care.</p>

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Clinical Relevance of Coronary Artery Calcifications in Radiation Oncology

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月21日

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  • Kevin Chen,
  • Jakub Bychowski,
  • Angelena Manova,
  • Maria Thomas,
  • Joanna C. Yang,
  • Pamela Samson,
  • Geoffrey D. Hugo,
  • Katelyn M. Atkins,
  • Joshua D. Mitchell,
  • Carmen Bergom

摘要

Purpose of the Review

Radiotherapy for malignancies within the chest improves oncologic outcomes but may increase the risk of cardiovascular disease, particularly coronary artery disease. Coronary artery calcifications (CAC) are a validated marker of coronary disease and can be readily identified on routine computed tomography scans used for radiotherapy planning and follow-up. However, its relevance in radiation oncology remains underrecognized.

Recent Findings

In this review, we examine the evidence supporting CAC identified on radiotherapy planning imaging as a prognostic marker of cardiovascular events. We then discuss how radiation may exacerbate the progression of CAC observed after radiation treatment. Finally, we discuss how considering radiation dose to the heart in the context of CAC may further strengthen our ability to predict cardiovascular outcomes.

Summary

Recognizing CAC both as a pre-existing risk factor for cardiovascular morbidity and a clinically relevant endpoint impacted by radiotherapy is essential to understanding its implementation into clinical practice to advance the personalization of cardio-oncologic care.