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Purpose of Review <p>Male breast cancer (MBC) represents less than 1% of breast cancer diagnoses but poses unique challenges due to delayed diagnosis, underrepresentation of males in clinical trials, and reliance on female-derived treatment paradigms. This review examines epidemiology, risk factors, clinical presentation, and advances in locoregional management of MBC.</p> Recent Findings <p>Population-based studies confirm comparable survival between mastectomy and breast-conserving surgery with radiation, though mastectomy remains more common. Sentinel lymph node biopsy is safe and effective, yet axillary dissection continues to be used commonly despite higher morbidity. Emerging data demonstrate survival benefits of adjuvant radiation, which is underutilized in males. Updated guidelines increasingly support tailored, less invasive management strategies for MBC.</p> Summary <p>Locoregional care of MBC is shifting toward evidence-based, individualized approaches. Improving outcomes will require prospective male-specific studies, better integration of radiation therapy, and enhanced survivorship strategies that address both oncologic and psychosocial needs.</p>

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Locoregional Management of Breast Cancer in Males

  • 期刊论文

  • 发表日期：

    2026年2月20日

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  • Sydney H. Smilen,
  • Claire P. Miller,
  • Michael R. Cassidy

摘要

Purpose of Review

Male breast cancer (MBC) represents less than 1% of breast cancer diagnoses but poses unique challenges due to delayed diagnosis, underrepresentation of males in clinical trials, and reliance on female-derived treatment paradigms. This review examines epidemiology, risk factors, clinical presentation, and advances in locoregional management of MBC.

Recent Findings

Population-based studies confirm comparable survival between mastectomy and breast-conserving surgery with radiation, though mastectomy remains more common. Sentinel lymph node biopsy is safe and effective, yet axillary dissection continues to be used commonly despite higher morbidity. Emerging data demonstrate survival benefits of adjuvant radiation, which is underutilized in males. Updated guidelines increasingly support tailored, less invasive management strategies for MBC.

Summary

Locoregional care of MBC is shifting toward evidence-based, individualized approaches. Improving outcomes will require prospective male-specific studies, better integration of radiation therapy, and enhanced survivorship strategies that address both oncologic and psychosocial needs.