Purpose of Review <p>Although the socioeconomic and racial/ethnic disparities in the diagnosis and management of female breast cancer have been widely examined, similar data regarding male breast cancer is currently lacking in comparison. The purpose of this study is to examine the effect of disparities and social determinants of health on the pathophysiology and clinical outcomes of patients with male breast cancer.</p> Recent Findings <p>Inequality in health care delivery is evident in all aspects of cancer care management, from prevention to end-of-life care. Racial/ethnic minorities as well as socioeconomically disadvantaged population subsets are characterized by increased cancer burden secondary to increased prevalence of risk factors as well as inadequate access to screening, diagnostic and treatment options. Furthermore, with much fewer publications and studies of male breast cancer treatment, as well as perceived decreased psychosocial importance of the breast appearance in males compared to females, there is a resultant surgical treatment disparity in providing surgical options for male breast cancer compared to female breast cancer.</p> Conclusion <p>Decreased understanding and awareness of male breast cancer, and lack of screening results in later stage of diagnosis which can affect the morbidity and quality of life of male breast cancer patients. Published studies on male breast cancer surgical treatment, indicate there has been a significant delay in the application of current surgical techniques such as nipple-sparing mastectomy (NSM) or areolar sparing mastectomy (ASM) in males, or breast conservation treatment, thereby affect quality of life of male breast cancer patients.</p>