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<p>This study presents a circular-cored photonic crystal fiber (PCF) for detecting five key variants of amino acid such as lysine, methionine, phenylalanine, histidine, and tryptophan. The proposed PCF is designed by utilizing zeonex as background material with a combination of elliptical and circular air holes, ensures compatibility with existing fabrication method, achieves excellent performance and validates the sensing capability of amino acids. Finite element method based on COMSOL multiphysics software has been utilized to organize and computationally investigate the model. The sensor is capable to operate in the broad spectral range of 1.8&#xa0;μm to 3.5&#xa0;μm. This proposed PCF achieves a peak relative sensitivity of 97.169% at 3.5&#xa0;μm for tryptophan among these five essential amino acids with minimal confinement loss of order 10<sup>⁻7</sup> dB/cm. These capabilities and endurance of the proposed PCF sensor make them a promising candidate for applications in biosensing, pharmaceutical sector and chemical sensing sector.</p>

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Design and performance analysis of a highly sensitive photonic crystal fiber based sensor for detection of human body amino acids

  • 期刊论文

  • 发表日期：

    2026年4月4日

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  • Anshu Tiwari,
  • Sapana Yadav,
  • Pratishtha Pandey,
  • Vikash Mourya,
  • D. K. Dwivedi,
  • Pooja Lohia,
  • R. K. Yadav,
  • Upendra Kulshrestha

摘要

This study presents a circular-cored photonic crystal fiber (PCF) for detecting five key variants of amino acid such as lysine, methionine, phenylalanine, histidine, and tryptophan. The proposed PCF is designed by utilizing zeonex as background material with a combination of elliptical and circular air holes, ensures compatibility with existing fabrication method, achieves excellent performance and validates the sensing capability of amino acids. Finite element method based on COMSOL multiphysics software has been utilized to organize and computationally investigate the model. The sensor is capable to operate in the broad spectral range of 1.8 μm to 3.5 μm. This proposed PCF achieves a peak relative sensitivity of 97.169% at 3.5 μm for tryptophan among these five essential amino acids with minimal confinement loss of order 10⁻7 dB/cm. These capabilities and endurance of the proposed PCF sensor make them a promising candidate for applications in biosensing, pharmaceutical sector and chemical sensing sector.