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<p>This article presents a performance analysis of fiber optical-based surface plasmon resonance (SPR) employing silver (Ag) and titanium dioxide (TiO<sub>2</sub>) for the <i>Helicobacter pylori (H. pylori).</i> The proposed sensor is composed of a Kretschmann configuration. This study employed the wavelength interrogation technique to analyze the sensor’s performance in terms of sensitivity, figure of merit (FoM), and limit of detection (LoD). Initially, the thickness optimisation of the considered is executed by observing better sensitivity and FoM. Furthermore, we demonstrate the impact of the proposed structure by comparing its performance with that of the conventional sensor. Subsequently, we explore the sensing parameters using the proposed structure for different concentrations of <i>H. pylori</i> bacteria, achieving a maximum sensitivity of 6812.50&#xa0;nm.<i>RIU</i><sup>− 1</sup>, a QF of 84.507 <i>RIU</i><sup>− 1</sup>, and a LoD of <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="12596_2025_2602_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="94" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:1.667\times\:1{0}^{-7}\)</EquationSource> </InlineEquation> RIU. Finally, a comparative study shows that the proposed sensor significantly outperforms the existing sensor.</p>

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Fiber-optic surface plasmon resonance nanosensor utilising Ag/TiO₂ layers for the detection of helical H. pylori with enhanced sensitivity and detection limit

  • 期刊论文

  • 发表日期：

    2025年2月22日

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  • Nasih Hma Salah

摘要

This article presents a performance analysis of fiber optical-based surface plasmon resonance (SPR) employing silver (Ag) and titanium dioxide (TiO2) for the Helicobacter pylori (H. pylori). The proposed sensor is composed of a Kretschmann configuration. This study employed the wavelength interrogation technique to analyze the sensor’s performance in terms of sensitivity, figure of merit (FoM), and limit of detection (LoD). Initially, the thickness optimisation of the considered is executed by observing better sensitivity and FoM. Furthermore, we demonstrate the impact of the proposed structure by comparing its performance with that of the conventional sensor. Subsequently, we explore the sensing parameters using the proposed structure for different concentrations of H. pylori bacteria, achieving a maximum sensitivity of 6812.50 nm.RIU− 1, a QF of 84.507 RIU− 1, and a LoD of \(\:1.667\times\:1{0}^{-7}\) RIU. Finally, a comparative study shows that the proposed sensor significantly outperforms the existing sensor.