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<p>Glucose has important roles in vertebrate embryogenesis. However, only trace amounts are present in the yolk. Recently, it was revealed that two teleost species and one shark species&#xa0;undergo gluconeogenesis in the yolk syncytial layer (YSL) and YSL-like tissue, respectively. Meanwhile, how glucose is supplemented during sturgeon development remains unclear. Sturgeons are an evolutionarily important sister group of teleosts. In this study, we investigated the gluconeogenic potential of Acipenseriformes during development. In sterlet <i>Acipenser ruthenus</i> and bester sturgeon (a hybrid of sterlet and beluga <i>Huso huso</i>), glucose levels increased during embryonic development. Furthermore, expression analysis of gluconeogenic genes in sterlet showed that the major genes were expressed in the endodermal cells at the marginal region of the yolk sac, suggesting that sturgeons perform gluconeogenesis in this tissue. Glycogen was also detected in the endoderm, implying that this tissue may serve as a sugar reservoir. These findings suggest that gluconeogenesis during embryonic development is an indispensable phenomenon shared among vertebrates. Further studies on other vertebrate groups will contribute to a better understanding of how vertebrates have adapted their yolk metabolism through evolutionary processes.</p>

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Gluconeogenesis and glycogen metabolism during development in sterlet Acipenser ruthenus and bester

  • 期刊论文

  • 发表日期：

    2025年6月14日

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  • Marino Shimizu,
  • Takako Matsuzaki,
  • Kaede Kobayashi,
  • Akihiro Aoyagi,
  • Makiha Kaneko,
  • Tatsuki Nagasawa,
  • Kiyoshi Hiraoka,
  • Fumiya Furukawa

摘要

Glucose has important roles in vertebrate embryogenesis. However, only trace amounts are present in the yolk. Recently, it was revealed that two teleost species and one shark species undergo gluconeogenesis in the yolk syncytial layer (YSL) and YSL-like tissue, respectively. Meanwhile, how glucose is supplemented during sturgeon development remains unclear. Sturgeons are an evolutionarily important sister group of teleosts. In this study, we investigated the gluconeogenic potential of Acipenseriformes during development. In sterlet Acipenser ruthenus and bester sturgeon (a hybrid of sterlet and beluga Huso huso), glucose levels increased during embryonic development. Furthermore, expression analysis of gluconeogenic genes in sterlet showed that the major genes were expressed in the endodermal cells at the marginal region of the yolk sac, suggesting that sturgeons perform gluconeogenesis in this tissue. Glycogen was also detected in the endoderm, implying that this tissue may serve as a sugar reservoir. These findings suggest that gluconeogenesis during embryonic development is an indispensable phenomenon shared among vertebrates. Further studies on other vertebrate groups will contribute to a better understanding of how vertebrates have adapted their yolk metabolism through evolutionary processes.