<p>Globally, skin diseases are emerging as the most common health problem. It initiates depressive disorder, and it also causes physical health distress. It rarely led to skin cancer in extreme cases. Diagnosing skin disease is subjective and time-consuming when it is performed by health experts manually. Hence, automatic skin disease prediction is required by both dermatologists and patients to enhance and accelerate treatment plans. Even though many machine-learning techniques are available to detect skin diseases, the timely prediction and accurate classification of skin lesions are still in demand. Hence, the Discrete Mycorrhizal Search Algorithm is used to optimize the novel LightGBM to meet this objective. Firstly, intrusions like noise elimination and hair removal are performed and then the image resizing takes place by utilizing the preprocessing pipelines. Subsequent to data pre-processing, the prime features are extracted using the convolutional self-attention based L2 regularization, thus minimizing the data complexity. At last, the extracted features are shifted to the final categorization phase which is done by the novel approach for effective classification of skin diseases. Two skin disease classification images, including datasets, the Skin Lesions Dermatoscopic Image dataset and Skin Cancer MNIST HAM10000, are selected to validate the classification performance. Comprehensive analyses are performed with significant measures that showed the proposed model attained better performances of 98.6%, 0.95, and 10.43&#xa0;s from accuracy, intersection of union, and execution time, respectively. The stability and robustness under different environmental conditions for clinical applications in skin disease detection and classification tasks are analyzed for making decisions in real-time scenarios.</p>