<p>Nose radius plays an essential role during machining, and it can influence the surface integrity of the machined parts. Consequently, it affects the material performance. However, the study on the effect of nose radius on the surface integrity of Ni-based alloys in nanofluid- minimum quantity lubrication (NMQL) assisted machining is limited, and almost no study has been carried out on alloy 925. A detailed experimental study on the effect of nose radii (0.8, 1.2, 1.6, 2.0, 2.4&#xa0;mm) on surface integrity (in terms of surface roughness, surface topography, microstructure, and microhardness) in the environment of nanofluid (coconut oil + h-BN) based MQL assisted end milling has been carried out. It is found that areal surface roughness (<i>S</i>_<i>a</i> and <i>S</i>_<i>q</i>) decreases with the increase in nose radius due to plowing action. Microhardness increases with the increase of nose radius due to higher cutting force, causing higher plastic deformation. Further, its consequences on the tribological performance of alloy 925 have been investigated with ball-on-disc in the reciprocating mode of tribological test. Results show that the machined component with the largest nose radius exhibits the lowest coefficient of friction because of its enhanced hardness and reduced surface roughness. Additionally, the machined component with the largest nose radius shows the lowest wear depth due to reduced friction between mating parts.</p>