Background <p>Several factors may influence adherence to the recommended twice-weekly strength activity guideline. Currently, there is a paucity of literature examining the associations of socioeconomic status (SES) on meeting the strength activity guideline among adults with disabilities. The purpose of this analysis is to examine the associations of SES on meeting the strength activity guideline among people with disabilities.</p> Methods <p>Using data from the 2017–2019 Behavioral Risk Factor Surveillance System, 14,425 adults with disabilities were classified as meeting or not meeting the strength activity guideline. Several SES variables, education, employment status, income level, household size, number of children, federal poverty level, partnered status, and homeownership were included in the analysis and served as independent variables. Separate unadjusted and adjusted logistic regression models were conducted to relate the effect of SES on meeting the strength activity guideline among people with disabilities.</p> Results <p>Among participants, 73.73% (95% CI [72.28, 75.15]) did not meet the guideline. Participants who were college or technical school graduates (aOR = 1.97, 95% CI [1.50, 2.57]) were more likely to meet the strength activity guideline, while other SES variables were found to be not statistically significantly associated with meeting the strength activity guideline (<i>p</i> &gt; .05).</p> Conclusions <p>Many SES factors were not associated with meeting the strength activity guideline among people with disabilities. Future targeted strategies may need to consider factors besides SES factors of people with disabilities to promote adherence to the strength activity guideline.</p>