<p>This paper discusses the possible prehistoric exploitation of the local copper ore deposit Mutěnín-Měděnka in the Domažlice region, western Bohemia (Central Europe). The research project deals with a possible relationship of the Bronze Age casting cakes discovered in this region to the historically documented mine of Mutěnín-Měděnka. The study is based on the detailed material analysis of the casting cakes and geochemical characterization of samples of chalcopyrite and secondary copper minerals from this deposit. The results considerably help to extend the so far very limited knowledge of the origin of the Bronze Age copper material in Bohemia and reveal its position in the complex structure of the material distribution network within Central Europe. Provenance analyses of copper raw material combine the determination of lead isotope ratios by HR-MC-ICP-MS with chemical composition data obtained by INAA, ICP-MS and ED-XRF. The research provides new evidence for the origin of the copper material in the threshold of Early and Middle Bronze Age in Bohemia. The origin of the analysed casting cakes can be traced to chalcopyrite deposits in the eastern and South-Eastern Alps. Possible exploitation of sulphidic copper minerals from the Mutěnín-Měděnka local deposit in the Late Bronze Age period has not been proven.</p>