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Background <p>Ultrasound and serum matrix metalloproteinase-7 (MMP-7) hold great value in distinguishing biliary atresia (BA) from other cholestatic diseases. This study aims to assess the accuracy of an artificial intelligence (AI) based diagnostic model of ultrasound combined with serum MMP-7 in discriminative diagnosis of BA.</p> Methods <p>This is a multicenter diagnostic study involving six medical centers in China. Patients with obstructive jaundice were enrolled. A set of morphological operators were employed to extract features of the ultrasound images to construct an AI algorithm. Logistic regression model was established with validation.</p> Results <p>Two cohorts with a total of 348 children with obstructive jaundice were recruited from January 2020 to April 2023. A retrospective cohort of 187 infants served as a training cohort; this included 56 BA and 131 non-BA patients. Serum MMP-7 testing model yielded an area under the receiver-operating characteristic curve (AUROC) of 0.916 [95% confidence interval (CI) =&#xa0;0.876–0.956], sensitivity of 94.6% (95% CI&#xa0;= 85.1%–98.9%), specificity of 88.6% (95% CI&#xa0;= 81.8%–93.5%), and accuracy of 90.4% (95% CI&#xa0;= 85.2%–94.2%). Values for ultrasound testing model were 0.945 (95% CI&#xa0;= 0.902–0.987), 98.2% (95% CI&#xa0;= 90.5%–99.9%), 91.6% (95% CI&#xa0;= 85.5%–95.7%), and 93.6% (95% CI&#xa0;= 89.1%–96.6%), respectively. The combined AI model obtained an AUROC of 0.985 (95% CI&#xa0;= 0.971–0.999), sensitivity of 98.2% (95% CI&#xa0;= 90.5%–99.9%), specificity of 93.1% (95% CI =&#xa0;84.4%–96.4%), and accuracy of 94.7% (95% CI&#xa0;= 90.4%–97.4%), respectively. Performance was confirmed using a multicenter prospective validation cohort of 161 patients that included 100 BA cases.</p> Conclusion <p>An AI model combining ultrasound and serum MMP-7 demonstrated robust high sensitivity and specificity in the differential diagnosis of BA.</p> Graphical abstract <p></p>

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Development and validation of a minimally invasive diagnostic model for biliary atresia using artificial intelligence

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月11日

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  • Jing-Ying Jiang,
  • Rui Dong,
  • Ying-Hua Sun,
  • Yi-Fan Yang,
  • Henkjan J. Verkade,
  • Xiao Cai,
  • Xiao-Li Xie,
  • Zhi-Bo Zhang,
  • Zhong-Xi Zhang,
  • Zhu Jin,
  • Min Du,
  • Jian-Jun Zhang,
  • Zhen Shen,
  • Wei-Li Yan,
  • Gong Chen,
  • Shan Zheng

摘要

Background

Ultrasound and serum matrix metalloproteinase-7 (MMP-7) hold great value in distinguishing biliary atresia (BA) from other cholestatic diseases. This study aims to assess the accuracy of an artificial intelligence (AI) based diagnostic model of ultrasound combined with serum MMP-7 in discriminative diagnosis of BA.

Methods

This is a multicenter diagnostic study involving six medical centers in China. Patients with obstructive jaundice were enrolled. A set of morphological operators were employed to extract features of the ultrasound images to construct an AI algorithm. Logistic regression model was established with validation.

Results

Two cohorts with a total of 348 children with obstructive jaundice were recruited from January 2020 to April 2023. A retrospective cohort of 187 infants served as a training cohort; this included 56 BA and 131 non-BA patients. Serum MMP-7 testing model yielded an area under the receiver-operating characteristic curve (AUROC) of 0.916 [95% confidence interval (CI) = 0.876–0.956], sensitivity of 94.6% (95% CI = 85.1%–98.9%), specificity of 88.6% (95% CI = 81.8%–93.5%), and accuracy of 90.4% (95% CI = 85.2%–94.2%). Values for ultrasound testing model were 0.945 (95% CI = 0.902–0.987), 98.2% (95% CI = 90.5%–99.9%), 91.6% (95% CI = 85.5%–95.7%), and 93.6% (95% CI = 89.1%–96.6%), respectively. The combined AI model obtained an AUROC of 0.985 (95% CI = 0.971–0.999), sensitivity of 98.2% (95% CI = 90.5%–99.9%), specificity of 93.1% (95% CI = 84.4%–96.4%), and accuracy of 94.7% (95% CI = 90.4%–97.4%), respectively. Performance was confirmed using a multicenter prospective validation cohort of 161 patients that included 100 BA cases.

Conclusion

An AI model combining ultrasound and serum MMP-7 demonstrated robust high sensitivity and specificity in the differential diagnosis of BA.

Graphical abstract