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<p>Background: To investigate the effects of prepubertal polycyclic aromatic hydrocarbons (PAHs) exposure on obesity indicators and height during puberty in girls. Methods: 524 girls were included in the data analysis. Urine samples were collected for four PAH metabolites: 1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthoic [2-OHNap], 2-hydroxyfluorene [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]. From April-December 2014 to November 2019, physical development was assessed semi-annually, amounting to a total of 11 assessments. Group-based Trajectory Models (GBTMs) were employed to fit the trajectories of girls’ body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), and height. The development of girls’ height was modeled using the SuperImposition by Translation And Rotation (SITAR) model. Logistic regression models and multiple linear regression models were used to analyze the relationships between PAH metabolites and trajectories of physical development indicators and between PAH metabolites and height growth patterns, respectively. Results: Log-transformed continuous 9-OHPhe concentrations was associated with obesity and peak height velocity (PHV). 1-OHPyr and 2-OHNap were associated with higher WHtR growth (OR = 1.736, 95%CI: (1.048, 2.876); OR = 2.588, 95%CI: (1.234, 5.427)); 2-OHFlu was associated with higher WHtR and WHR growth (OR = 2.123, 95%CI: (1.014, 4.446); OR = 1.765, 95%CI: (1.038, 3.004)); 9-OHPhe was associated with higher WC, HC, and WHtR growth (OR = 2.989, 95%CI: (1.215, 7.35); OR = 2.655, 95%CI: (1.189, 5.933); OR = 2.146, 95%CI: (1.043, 4.413); OR = 2.441, 95%CI: (1.088, 5.361)). Compared to the low exposure group, girls with moderate levels of 1-OHPyr metabolite had slower PHV (β=-0.106; <i>P</i> = 0.046); and girls with high levels of 2-OHNap metabolite had lower height growth velocity (β=-0.108; <i>P</i> = 0.045) and slower PHV (β=-0.128; <i>P</i> = 0.017). Conclusions: Prepubertal exposure to PAHs may be associated with general obesity, abdominal obesity, and height dysplasia in girls.</p>

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The Association Between Prepubertal Polycyclic Aromatic Hydrocarbon Exposure and Physical Development During Puberty in Chinese Girls: A Longitudinal Study

  • 期刊论文

  • 发表日期：

    2026年3月9日

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  • Yan Li,
  • Zongwei He,
  • Qin Zhang,
  • Shudan Liu,
  • Jie Luo,
  • Yu Tian,
  • Yujie Wang,
  • Qin Liu

摘要

Background: To investigate the effects of prepubertal polycyclic aromatic hydrocarbons (PAHs) exposure on obesity indicators and height during puberty in girls. Methods: 524 girls were included in the data analysis. Urine samples were collected for four PAH metabolites: 1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthoic [2-OHNap], 2-hydroxyfluorene [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]. From April-December 2014 to November 2019, physical development was assessed semi-annually, amounting to a total of 11 assessments. Group-based Trajectory Models (GBTMs) were employed to fit the trajectories of girls’ body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), and height. The development of girls’ height was modeled using the SuperImposition by Translation And Rotation (SITAR) model. Logistic regression models and multiple linear regression models were used to analyze the relationships between PAH metabolites and trajectories of physical development indicators and between PAH metabolites and height growth patterns, respectively. Results: Log-transformed continuous 9-OHPhe concentrations was associated with obesity and peak height velocity (PHV). 1-OHPyr and 2-OHNap were associated with higher WHtR growth (OR = 1.736, 95%CI: (1.048, 2.876); OR = 2.588, 95%CI: (1.234, 5.427)); 2-OHFlu was associated with higher WHtR and WHR growth (OR = 2.123, 95%CI: (1.014, 4.446); OR = 1.765, 95%CI: (1.038, 3.004)); 9-OHPhe was associated with higher WC, HC, and WHtR growth (OR = 2.989, 95%CI: (1.215, 7.35); OR = 2.655, 95%CI: (1.189, 5.933); OR = 2.146, 95%CI: (1.043, 4.413); OR = 2.441, 95%CI: (1.088, 5.361)). Compared to the low exposure group, girls with moderate levels of 1-OHPyr metabolite had slower PHV (β=-0.106; P = 0.046); and girls with high levels of 2-OHNap metabolite had lower height growth velocity (β=-0.108; P = 0.045) and slower PHV (β=-0.128; P = 0.017). Conclusions: Prepubertal exposure to PAHs may be associated with general obesity, abdominal obesity, and height dysplasia in girls.