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<p>Aging is a key risk factor for mild cognitive impairment (MCI). Additionally, serum lead (Pb) level has been associated with neurotoxicity and cognitive decline. However, evidence regarding their association with MCI among older adults with different nutritional statuses is still scarce. This study aimed to assess the association between serum Pb level and MCI in older adults from Mexico City. A total of 468 older adults were included in this cross-sectional study. Sociodemographic, anthropometric, and clinical data were analyzed. Serum Pb level was measured by inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was evaluated with the Mini-Mental State Examination (MMSE). Among participants, 18% exhibited MCI, and the frequencies of underweight, overweight, and obesity were 15.6%, 22.4%, and 13.0%, respectively. Age was negatively associated with MMSE score (β = -0.046 ± 0.023, <i>p</i> = 0.049), while education level was related to an increase in MMSE score (β = 0.432 ± 0.148, <i>p</i> = 0.004). Mean serum Pb level was 3.2 ± 2.7&#xa0;µg/dL and was significantly higher in women than men (<i>p</i> = 0.018). Serum Pb level was associated with MCI risk (Odds ratio = 1.296, 95% confidence interval 1.028–1.633, <i>p</i> = 0.028) in the underweight group, where a negative relationship between serum Pb level and MMSE score was also observed (β = -0.289 ± 0.139, <i>p</i> = 0.041). Our results suggest that serum Pb levels are associated with MCI risk and low global cognitive performance, particularly in underweight older adults from Mexico City.</p>

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Serum Lead Levels are Associated with Mild Cognitive Impairment Risk in Underweight Older Adults

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Estefanía Chávez-Prieto,
  • Héctor Hernández-Mendoza,
  • Bertha Irene Juárez Flores,
  • Paola García-DelaTorre,
  • Sergio Sánchez-García,
  • Miguel Cruz,
  • Araceli Pérez-Bautista,
  • Andrés Rocha-Aguado,
  • Miguel Vazquez-Moreno,
  • María Judith Rios-Lugo

摘要

Aging is a key risk factor for mild cognitive impairment (MCI). Additionally, serum lead (Pb) level has been associated with neurotoxicity and cognitive decline. However, evidence regarding their association with MCI among older adults with different nutritional statuses is still scarce. This study aimed to assess the association between serum Pb level and MCI in older adults from Mexico City. A total of 468 older adults were included in this cross-sectional study. Sociodemographic, anthropometric, and clinical data were analyzed. Serum Pb level was measured by inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was evaluated with the Mini-Mental State Examination (MMSE). Among participants, 18% exhibited MCI, and the frequencies of underweight, overweight, and obesity were 15.6%, 22.4%, and 13.0%, respectively. Age was negatively associated with MMSE score (β = -0.046 ± 0.023, p = 0.049), while education level was related to an increase in MMSE score (β = 0.432 ± 0.148, p = 0.004). Mean serum Pb level was 3.2 ± 2.7 µg/dL and was significantly higher in women than men (p = 0.018). Serum Pb level was associated with MCI risk (Odds ratio = 1.296, 95% confidence interval 1.028–1.633, p = 0.028) in the underweight group, where a negative relationship between serum Pb level and MMSE score was also observed (β = -0.289 ± 0.139, p = 0.041). Our results suggest that serum Pb levels are associated with MCI risk and low global cognitive performance, particularly in underweight older adults from Mexico City.