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<p>Trihalomethanes (THMs) are the most common and diverse disinfection byproducts in drinking water. Long-term exposure to THMs may result in cancer and severe reproductive and developmental problems. However, few studies have evaluated the potential effects of THMs on the cardiovascular system. Blood pressure (BP) parameters (including systolic BP, diastolic BP, pulse pressure (PP)), lipid parameters (including total cholesterol and triglycerides), and urinary THM concentrations (trichloromethane (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and tribromomethane (TBM)) were measured in 182 adults at a medical examination center in Wuxi, China. Logistic and linear regression were used to analyze the relationship between urinary THM levels and BP parameters. DBCM, brominated THM (Br-THM), and total trihalomethanes (TTHMs) positively correlated with PP (<i>P</i> &lt; 0.05). Logistic regression models showed significant trends (<i>P</i> &lt; 0.05) towards increasing odds ratios for PP with increasing urinary THMs. The linear regression model also showed that DBCM and Br-THM were significantly positively correlated with PP (<i>P</i> &lt; 0.05) after adjusting for confounding factors. The results of this study suggest that THM exposure influences BP in adults. However, more prospective and experimental studies are needed in the future to validate our findings.</p>

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Positive Dose–Response Relationship Between Urinary Trihalomethanes and Blood Pressure in Adults in Wuxi, China

  • 期刊论文

  • 发表日期：

    2025年2月20日

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  • Shunan Wang,
  • Qianqian Wang,
  • Chao Yang,
  • Li Yang,
  • Lingling Xu,
  • Run Zhou,
  • Limei Chen,
  • Yao Li,
  • Pengfei Zhu,
  • Xinliang Ding

摘要

Trihalomethanes (THMs) are the most common and diverse disinfection byproducts in drinking water. Long-term exposure to THMs may result in cancer and severe reproductive and developmental problems. However, few studies have evaluated the potential effects of THMs on the cardiovascular system. Blood pressure (BP) parameters (including systolic BP, diastolic BP, pulse pressure (PP)), lipid parameters (including total cholesterol and triglycerides), and urinary THM concentrations (trichloromethane (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and tribromomethane (TBM)) were measured in 182 adults at a medical examination center in Wuxi, China. Logistic and linear regression were used to analyze the relationship between urinary THM levels and BP parameters. DBCM, brominated THM (Br-THM), and total trihalomethanes (TTHMs) positively correlated with PP (P < 0.05). Logistic regression models showed significant trends (P < 0.05) towards increasing odds ratios for PP with increasing urinary THMs. The linear regression model also showed that DBCM and Br-THM were significantly positively correlated with PP (P < 0.05) after adjusting for confounding factors. The results of this study suggest that THM exposure influences BP in adults. However, more prospective and experimental studies are needed in the future to validate our findings.