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<p>The case involved a 35-year-old female patient in the fifth month of pregnancy. The patient complained of dysphagia in the early stages of pregnancy and was referred to our hospital after developing dyspnea. An MRI revealed an 8&#xa0;cm tumor in the anterior mediastinum compressing the airway. The fetus was delivered via emergency cesarean section, and a cervical lymph node biopsy confirmed squamous cell carcinoma. The tumor was diagnosed as an anterior mediastinal tumor of unknown primary origin, and treatment with nanoparticle albumin-bound paclitaxel (nab-PTX) plus Carboplatin (CBDCA) resulted in significant tumor shrinkage. Following shrinkage, the tumor was ultimately diagnosed as esophageal cancer. Subsequently, recurrence in the esophagus and brain metastasis were detected. Still, after undergoing radiation therapy, surgical treatment, and chemotherapy, no recurrence was observed for more than one year after the final treatment. The results of this study demonstrate that the combination therapy of nab-PTX plus CBDCA is highly effective not only for lung squamous cell carcinoma but also for esophageal squamous cell carcinoma.</p>

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A young pregnant woman with oesophageal cancer who responded to carboplatin plus nab-paclitaxel therapy

  • 期刊论文

  • 发表日期：

    2026年7月13日

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  • Yoshinori Kikuchi,
  • Kazuhisa Yamaguchi,
  • Munehiro Wakabayashi,
  • Naobumi Tochigi,
  • Naoyuki Harada,
  • Atsuro Terahara,
  • Takahisa Matsuda

摘要

The case involved a 35-year-old female patient in the fifth month of pregnancy. The patient complained of dysphagia in the early stages of pregnancy and was referred to our hospital after developing dyspnea. An MRI revealed an 8 cm tumor in the anterior mediastinum compressing the airway. The fetus was delivered via emergency cesarean section, and a cervical lymph node biopsy confirmed squamous cell carcinoma. The tumor was diagnosed as an anterior mediastinal tumor of unknown primary origin, and treatment with nanoparticle albumin-bound paclitaxel (nab-PTX) plus Carboplatin (CBDCA) resulted in significant tumor shrinkage. Following shrinkage, the tumor was ultimately diagnosed as esophageal cancer. Subsequently, recurrence in the esophagus and brain metastasis were detected. Still, after undergoing radiation therapy, surgical treatment, and chemotherapy, no recurrence was observed for more than one year after the final treatment. The results of this study demonstrate that the combination therapy of nab-PTX plus CBDCA is highly effective not only for lung squamous cell carcinoma but also for esophageal squamous cell carcinoma.