Scholarlink

Background <p>Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with low malignant potential. Although SPNs often grow slowly and may reach a large size before detection, tumors &gt; 20&#xa0;cm in diameter are extremely rare.</p> Case presentation <p>A 45-year-old asymptomatic woman was incidentally found to have a large abdominal mass during a routine health examination. Serum CEA and CA19-9 levels were within normal limits. Contrast-enhanced CT revealed a well-encapsulated cystic mass measuring approximately 20&#xa0;cm, with heterogeneous internal density and focal mural thickening. MRI demonstrated a predominantly cystic lesion with high signal intensity on T2-weighted images and restricted diffusion in the solid components. Complete surgical resection was performed, with an operative time of 4&#xa0;h 9&#xa0;min and blood loss of 42&#xa0;mL. Pathological examination confirmed a 22 × 22-cm SPN with typical histological and immunohistochemical features. Postoperative portal vein thrombosis was successfully treated with anticoagulation therapy. The patient was discharged on postoperative day 17 and remains recurrence-free 5&#xa0;years after surgery.</p> Conclusion <p>This case demonstrates that even extremely large SPNs can be safely resected with excellent long-term outcomes, and tumor size alone should not be considered an indicator of aggressive biological behavior.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Extremely large solid pseudopapillary neoplasm of the pancreas

  • 期刊论文

  • 发表日期：

    2026年6月15日

查看全文
  • Richi Nakatake,
  • Hiroaki Kitade,
  • Hidesuke Yanagida,
  • Morihiko Ishizaki,
  • Tetsuya Okuyama,
  • Yoshiko Uemura,
  • Sohei Satoi

摘要

Background

Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with low malignant potential. Although SPNs often grow slowly and may reach a large size before detection, tumors > 20 cm in diameter are extremely rare.

Case presentation

A 45-year-old asymptomatic woman was incidentally found to have a large abdominal mass during a routine health examination. Serum CEA and CA19-9 levels were within normal limits. Contrast-enhanced CT revealed a well-encapsulated cystic mass measuring approximately 20 cm, with heterogeneous internal density and focal mural thickening. MRI demonstrated a predominantly cystic lesion with high signal intensity on T2-weighted images and restricted diffusion in the solid components. Complete surgical resection was performed, with an operative time of 4 h 9 min and blood loss of 42 mL. Pathological examination confirmed a 22 × 22-cm SPN with typical histological and immunohistochemical features. Postoperative portal vein thrombosis was successfully treated with anticoagulation therapy. The patient was discharged on postoperative day 17 and remains recurrence-free 5 years after surgery.

Conclusion

This case demonstrates that even extremely large SPNs can be safely resected with excellent long-term outcomes, and tumor size alone should not be considered an indicator of aggressive biological behavior.