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<p>An MRI of a 25-year-old adult male patient after an episode of acute pancreatitis revealed a multiloculated pancreatic head cyst with a mural nodule. Endoscopic biopsy and molecular analysis showed wild-type KRAS, GNAS and TP53. Due to diagnostic uncertainty, a surgical resection was performed and revealed acinar cystic transformation (ACT), a rare benign lesion. ACT should be considered in differential diagnosis of pancreatic cysts, especially in young patients.</p>

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Acinar cystic transformation of pancreas as a rare cause of acute pancreatitis and a diagnostic challenge in a young male

  • 期刊论文

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  • 发表日期：

    2026年4月13日

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  • Christos Longros,
  • Dietrich Alexander Ruess

摘要

An MRI of a 25-year-old adult male patient after an episode of acute pancreatitis revealed a multiloculated pancreatic head cyst with a mural nodule. Endoscopic biopsy and molecular analysis showed wild-type KRAS, GNAS and TP53. Due to diagnostic uncertainty, a surgical resection was performed and revealed acinar cystic transformation (ACT), a rare benign lesion. ACT should be considered in differential diagnosis of pancreatic cysts, especially in young patients.